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Exploring the Role of TRAF6-TAK1 Pathway in Podocyte Pyroptosis and Its Implications for Primary Membranous Nephropathy Therapy.
Inflammation
January 2025
Department of Nephrology, the First Affiliated Hospital of Bengbu Medical University, No. 287, Changhuai Road, Longzihu District, Bengbu, 233000, Anhui Province, China.
Primary membranous nephropathy (PMN) is a prevalent renal disorder characterized by immune-mediated damage to the glomerular basement membrane, with recent studies highlighting the significant role of pyroptosis in its progression. In this study, we investigate the molecular mechanisms underlying PMN, focusing on the role of Tumor necrosis factor receptor-associated factor 6 (TRAF6) in promoting disease advancement. Specifically, we examine how TRAF6 facilitates PMN progression by inducing the ubiquitination of Transforming growth factor-beta-activated kinase 1 (TAK1), which in turn activates the Gasdermin D (GSDMD)/Caspase-1 axis, leading to podocyte pyroptosis.
View Article and Find Full Text PDFBCT-Net: semantic-guided breast cancer segmentation on BUS.
Med Biol Eng Comput
January 2025
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, China.
Accurately and swiftly segmenting breast tumors is significant for cancer diagnosis and treatment. Ultrasound imaging stands as one of the widely employed methods in clinical practice. However, due to challenges such as low contrast, blurred boundaries, and prevalent shadows in ultrasound images, tumor segmentation remains a daunting task.
View Article and Find Full Text PDFMechanism of microbial action of the inoculated nitrogen-fixing bacterium for growth promotion and yield enhancement in rice (Oryza sativa L.).
Adv Biotechnol (Singap)
September 2024
College of Agronomy, Hunan Agricultural University, Changsha, 410128, China.
The use of nitrogen-fixing bacteria in agriculture is increasingly recognized as a sustainable method to boost crop yields, reduce chemical fertilizer use, and improve soil health. However, the microbial mechanisms by which inoculation with nitrogen-fixing bacteria enhance rice production remain unclear. In this study, rice seedlings were inoculated with the nitrogen-fixing bacterium R3 (Herbaspirillum) at the rhizosphere during the seedling stage in a pot experiment using paddy soil.
View Article and Find Full Text PDFThe Daily Process of Interpersonal Conflict and Mood among Chinese Adolescents: A Multilevel Moderated Mediation Analysis of Cognitive Appraisal, Social Support and Psychological Capital.
Res Child Adolesc Psychopathol
January 2025
School of Developmental Psychology, Faculty of Psychology, Beijing Normal University, 19 Xinjiekouwai Avenue, Haidian District, Beijing, 100875, China.
A growing body of literature has confirmed the within-person process from interpersonal conflict to adolescent mood on a day-to-day timescale. However, research on how, when and for whom adolescent interpersonal conflict relates to their daily mood is underdeveloped. This study examined whether interpersonal conflict is related to mood through threat appraisal and self-blaming attribution and whether these relationships would be moderated by daily social support and psychological capital.
View Article and Find Full Text PDFElimination of Decapod iridovirus 1 (DIV1) infection at high water temperature: a new environmental control strategy.
Adv Biotechnol (Singap)
March 2024
College of Fisheries, Guangdong Ocean University, Zhanjiang, Guangdong, China.
Decapod iridovirus 1 (DIV1) poses a major challenge to sustainable shrimp farming and poses a serious hazard to aquaculture industry. This study investigated the complex interaction between DIV1 infection and water temperature, focusing on the effect of high temperature on DIV1 infection due to Penaeus monodon. Using models of latent and acute infection, the study revealed the response of P.
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