AI Article Synopsis
- Methylazoxymethanol is a strong carcinogen linked to tumor development, especially in the small intestine and colon, after a single dose.
- Prior research suggests that the enzyme alcohol dehydrogenase converts this carcinogen into a harmful alkylating agent.
- When rats were treated with the alcohol dehydrogenase inhibitor pyrazole before exposure to the carcinogen, intestinal and colonic tumors were prevented, but the rats still developed other tumors in the skin and kidneys, indicating other enzymes may activate the carcinogen in different organs.
Article Abstract
Methylazoxymethanol is a potent carcinogen and induces tumors predominantly of the small intestine and colon following a single injection. Previous data indicated that alcohol dehydrogenase could convert this carcinogen to a reactive alkylating agent. Rats were treated with an inhibitor of this enzyme, pyrazole, 2 hr prior to their receiving the carcinogen. The development of intestinal and colonic tumors was prevented. The rats did, however, develop numerous tumors of the skin and kidney. Analyses of the complete autopsies are presented. The data indicate that intestinal and colonic alcohol dehydrogenase plays a role in the tumorigenic effects of methylazoxymethanol and that other non-pyrazole-sensitive enzymes exist in other organs that can also activate this carcinogen.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!