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Purpose: To assess differences in safety and efficacy between 24 and 18 Fr pneumatic balloon dilators for percutaneous nephrolithotripsy (PCNL) of renal stones between 10 and 20 mm.

Methods: Patients were randomized to dilatation with a 24 Fr (Group A) versus 18 Fr (Group B) Ultraxx pneumatic dilator (Cook Medical). In all procedures percutaneous puncture was performed under ultrasound guidance.

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Rationale: Urinary calculi are hard mineral deposits that typically require medication or surgery, such as lithotripsy. This case report presents traditional Chinese exercises (TCEs) as a potential alternative for stone expulsion.

Patient Concerns: A 41-year-old male with no history of urinary tract stones, experienced sudden severe lower back and abdominal pain accompanied by nausea and vomiting.

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Urolithiasis affects a significant portion of the global population, causing discomfort and pain. Unfortunately, effective drugs to treat this disorder are currently unavailable due to multiple mechanisms and an incomplete understanding of its causes. Consequently, drugs with multiple targets could be a safer and more effective remedy for treating urolithiasis.

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Kidney stones typically present as renal colic in emergency departments (EDs), where patients experience severe pain and often require parenteral therapy for symptom management. The economic burden associated with managing kidney stones exceeds USD 5 billion annually in the US and accounts for more than a million visits to EDs each year. There is clear evidence emphasizing the need for innovative and alternative pain control options for patients with renal colic.

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Marcello Malpighi's failing health, death, and the remarkable story of his mortal remains.

J Med Biogr

January 2025

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA.

Marcello Malpighi, renowned as the founder of microscopic anatomy, faced many challenges throughout his life. Among these was his frail health, which deteriorated in his early 40s when he developed kidney stones. He struggled with arthritic pain and heart palpitations, which, along with his renal condition, gradually became worse as he got older.

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