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Background: Prior to the introduction of disease-modifying treatments (DMTs), children with type 1 spinal muscular atrophy (SMA) typically did not survive beyond the age of 2 years; management was mainly palliative. Novel therapies have made this a treatable condition, resulting in increased life expectancy and more time spent upright. Survival and improved function mean spinal asymmetry is a new complication with limited data on its prevalence and severity and no current guidelines on management and treatment.
View Article and Find Full Text PDFHeat strain in different hot environments hiking in wildland firefighting garments.
Appl Physiol Nutr Metab
January 2025
Center for Research and Education in Special Environments (CRESE), Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo NY 14214, USA.
Wildland firefighters can work at high intensity in hot environments for extended periods of time. The resulting heat strain may be modified by the environmental conditions (i.e.
View Article and Find Full Text PDFArticle Synopsis
- - This research examined how heat affects the upper body of firefighters and their protective gear after intense heat exposure, confirming a hypothesis that the head and helmet would be the hottest areas.
- - Twenty participants exercised for 21 minutes in a humid and hot environment while wearing firefighter gear, with various body parts and PPE analyzed for temperature.
- - Results showed the head, chest, and upper back were the hottest post-exercise, while the abdomen was the coolest, highlighting the need for better cooling strategies for firefighters.
Etched stainless steel wire modified with conjugated microporous polymers-F6 for jacket-free stir bar sorptive extraction of benzoylureas in juice sample.
Analyst
June 2024
Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430072, China.
Benzoylurea (BU) insecticides have been widely used for pest control as third-generation insecticides. Considering that their residues in food may cause adverse effects on human health, the upper limits of BUs remaining in food have been set by the administration. Therefore, it is essential to develop a sensitive and efficient analytical method to determine the residues of BUs in food.
View Article and Find Full Text PDFAn enhanced method for evaluating the effectiveness of protective devices for road safety application.
Accid Anal Prev
August 2024
Dipartimento di Ingegneria Industriale, Università degli Studi di Firenze, Via di Santa Marta 3, 50139 Firenze, Italy.
This paper presents an enhanced probabilistic approach to estimate the real-world safety performance of new device concepts for road safety applications from the perspective of Powered Two-Wheeler (PTW) riders who suffer multiple injuries in different body regions. The proposed method estimates the overall effectiveness of safety devices for PTW riders by correlating computer simulations with various levels of actual injuries collected worldwide from accident databases. The study further develops the methodology initially presented by Johnny Korner in 1989 by introducing a new indicator, Global Potential Damage (GPD), that overcomes the limitations of the original method, encompassing six biomechanical injury indices estimated in five body regions.
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