AI Article Synopsis

  • The study investigates how sepsis affects lipid metabolism, particularly focusing on changes in adipose tissue enzymes following E. coli infection in rats.
  • Rats infected with E. coli showed significantly higher serum triglyceride levels compared to control rats, indicating a disruption in lipid processing.
  • The findings suggest that the increased triglycerides may arise from reduced lipid clearance from the blood and heightened lipid production in the liver due to decreased activity of enzymes like lipoprotein lipase (LPL) and fatty acid synthetase (FAS).

Article Abstract

The effects of sepsis on lipid metabolism have not been clearly defined. This study was designed to observe the changes in adipose tissue lipoprotein lipase (LPL) and fatty acid synthetase (FAS) after administration of Escherichia coli bacteria. Male Lewis rats, weighing 245 to 270 g, were assigned to two groups and fed a powdered chow diet for 14 days. On day 14, one group was inoculated with E coli. Twenty-four hours later, both groups were killed by decapitation. Serum triglyceride levels were significantly elevated in the E coli-treated rats. Adipose tissue LPL and FAS activity was significantly decreased by 50% in E coli-treated rats compared with the control rats. These results suggest that the elevated serum triglyceride levels associated with sepsis maybe caused by a decreased rate of clearance of lipids from the blood and an increased rate of hepatic lipid synthesis.

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http://dx.doi.org/10.1001/archsurg.1982.01380260028005DOI Listing

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