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Apixaban versus aspirin for stroke prevention in people with subclinical atrial fibrillation and a history of stroke or transient ischaemic attack: subgroup analysis of the ARTESiA randomised controlled trial.
Lancet Neurol
February 2025
Department of Medicine, McMaster University, Population Health Research Institute, Hamilton, ON, Canada.
Background: People with subclinical atrial fibrillation are at increased risk of stroke, albeit to a lesser extent than those with clinical atrial fibrillation, leading to an ongoing debate regarding the benefit of anticoagulation in these individuals. In the ARTESiA trial, the direct-acting oral anticoagulant apixaban reduced stroke or systemic embolism compared with aspirin in people with subclinical atrial fibrillation, but the risk of major bleeding was increased with apixaban. In a prespecified subgroup analysis of ARTESiA, we tested the hypothesis that people with subclinical atrial fibrillation and a history of stroke or transient ischaemic attack, who are known to have an increased risk of recurrent stroke, would show a greater benefit from oral anticoagulation for secondary stroke prevention compared with those without a history of stroke or transient ischaemic attack.
View Article and Find Full Text PDFLatin America's Dengue Outbreak Poses a Global Health Threat.
Viruses
January 2025
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 5508-900, Brazil.
Dengue fever, caused by the dengue virus (DENV), poses a significant global health challenge, particularly in tropical and subtropical regions. Recent increases in indigenous DENV cases in Europe are concerning, reflecting rising incidence linked to climate change and the spread of mosquitoes. These vectors thrive under environmental conditions like temperature and humidity, which are increasingly influenced by climate change.
View Article and Find Full Text PDFComparison of Manual, Automatic, and Voice Control in Wheelchair Navigation Simulation in Virtual Environments: Performance Evaluation of User and Motion Sickness.
Sensors (Basel)
January 2025
Instituto de Ciencias Aplicadas y Tecnología (ICAT), Universidad Nacional Autónoma de México, Ciudad de México C.P. 04510, Mexico.
Mobility is essential for individuals with physical disabilities, and wheelchairs significantly enhance their quality of life. Recent advancements focus on developing sophisticated control systems for effective and efficient interaction. This study evaluates the usability and performance of three wheelchair control modes manual, automatic, and voice controlled using a virtual reality (VR) simulation tool.
View Article and Find Full Text PDFFactors Influencing the Choice Between Multi-Target Stool DNA and Colonoscopy for Colorectal Cancer Screening Among Alaska Native Peoples.
Life (Basel)
January 2025
Alaska Native Tribal Health Consortium, 3900 Ambassador Dr., Anchorage, AK 99508, USA.
The Alaska Tribal Health System is increasing colorectal cancer (CRC) screening among Alaska Native (AN) peoples, who experience the highest CRC rate in the world. Through a clinical trial (NCT04336397), AN people living in rural/remote Alaska were offered either the previously unavailable multi-target stool DNA test (mt-sDNA; Cologuard) or colonoscopy. From April 2022 to August 2024, 113 (59%) people who completed mt-sDNA testing and 51 (39%) who completed a colonoscopy procedure participated in a survey on factors influencing their screening test choice.
View Article and Find Full Text PDFCritical mobility in policy making for epidemic containment.
Sci Rep
January 2025
Instituto de Física Interdisciplinar y Sistemas Complejos IFISC (CSIC-UIB), Palma de Mallorca, 07122, Spain.
When considering airborne epidemic spreading in social systems, a natural connection arises between mobility and epidemic contacts. As individuals travel, possibilities to encounter new people either at the final destination or during the transportation process appear. Such contacts can lead to new contagion events.
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