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Rg1 improves Alzheimer's disease by regulating mitochondrial dynamics mediated by the AMPK/Drp1 signaling pathway.
J Ethnopharmacol
January 2025
Hubei University of Chinese Medicine, Basic Medical College, Wuhan, Hubei, 430070, China; Engineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Wuhan, Hubei, 430070, China; Hubei Shizhen Laboratory, Wuhan, Hubei, 430070, China. Electronic address:
Ethnopharmacological Relevance: Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a complex pathogenesis that includes Aβ deposition, abnormal phosphorylation of tau protein, chronic neuroinflammation, and mitochondrial dysfunction. In traditional medicine, ginseng is revered as the 'king of herbs'. Ginseng has the effects of greatly tonifying vital energy, strengthening the spleen and benefiting the lungs, generating fluids and nourishing the blood, and calming the mind while enhancing intelligence.
View Article and Find Full Text PDFHaemolymphatic tissues of captive boa constrictor (Boa constrictor): Morphological features in healthy individuals and with boid inclusion body disease.
Dev Comp Immunol
January 2025
Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Switzerland.
Knowledge on the structure and composition of the haematopoietic tissue (HT) is essential to understand the basic immune functions of the immune system in any species. For reptiles, it is extremely limited, hence we undertook an in-depth in situ investigation of the HT (bone marrow, thymus, spleen, lymphatic tissue of the alimentary tract) in the common boa (Boa constrictor). We also assessed age- and disease-related changes, with a special focus on Boid Inclusion Body Disease, a highly relevant reptarenavirus-associated disease in boid snakes.
View Article and Find Full Text PDFVon Willebrand Factor in Weibel-Palade Bodies of Endothelial Cells Involved in the Immune Response to Hirame Novirhabdovirus Infection in a Teleost Paralichthys olivaceus.
J Fish Dis
December 2024
Laboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.
von Willebrand factor (vWF) is a large multimeric sialoglycoprotein that plays key roles in normal haemostasis, inflammation regulation, angiogenesis and cancer metastasis in mammals. The gene, protein sequences and functions of vWF in flounder Paralichthys olivaceus (PovWF) were analysed in this study. PovWF possesses an 8550-bp open reading frame (ORF) that encodes a 2849 amino acid protein.
View Article and Find Full Text PDFActivation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway.
Exp Gerontol
December 2024
Department of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:
Article Synopsis
- Diabetes mellitus (DM) is linked to cognitive impairment, with the study focusing on spleen tyrosine kinase (SYK) as a potential mechanism behind this connection.
- In experiments on diabetic mice, cognitive deficits were observed, and SYK activation was associated with increased neuronal cell death (pyroptosis) in the hippocampus.
- The research showed that inhibiting SYK significantly improved cognitive function and reduced signs of neuronal damage, suggesting that targeting SYK could be a therapeutic approach for cognitive issues in DM patients.
Anti-toxoplasmic effects of celecoxib alone and combined with spiramycin in experimental mice.
Acta Trop
December 2024
Department of Clinical and Molecular Parasitology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Even though toxoplasmosis is a worldwide parasitic disease caused by Toxoplasma gondii (T. gondii), the available drugs used for the treatment of symptomatic toxoplasmosis have multiple drawbacks. So, there is a considerable need to discover new potential therapeutic agents.
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