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Capecitabine-induced acute toxic leukoencephalopathy.
Neurotoxicology
September 2017
APHP, Hospital Pitié-Salpêtrière, Neuroradiology Department, Paris, France; Sorbonne Universités, Pierre and Marie Curie Faculty of Medicine, Paris, France. Electronic address:
A 45-year-old woman was treated by Capecitabine (Xeloda) during 6days for breast cancer with metastatic bone lesions when she presented with nausea, headaches, muscle cramps, dysarthria and swallowing disorders. A stroke was first suspected. Brain CT was normal.
View Article and Find Full Text PDFClinical and imaging diagnosis for heredodegenerative diseases.
Handb Clin Neurol
April 2014
Department of Pediatric Radiology, Hôpital Necker - Enfants Malades and Medical Faculty, Université Paris Descartes, Paris, France. Electronic address:
Clinical features (progressive psychomotor retardation, seizures, movement disorders and motor signs in both central and peripheral systems, sensorineural defects, and psychiatric symptoms) and brain imaging are the keys to diagnosis. CT is indicated for the detection of calcifications and blood, and for angiography. MRI in all three axes requires T1, T2, FLAIR (from 1 year on), eventually T2* or contrast administration, and diffusion in any acute condition.
View Article and Find Full Text PDFClinical characteristics of pseudostroke conditions in connection with the nature of somatic pathology, responsible for those conditions, were investigated in 52 patients. According to the character of somatic pathology all the elder patients were divided into 4 groups: myocardial infarction and progressive heart insufficiency, acute lung and heart insufficiency, inflammatory kidney disorders with signs of renal insufficiency, different intoxications. According to the results of macroscopic brain investigation, there were post-ischaemic cysts.
View Article and Find Full Text PDFDrug and nutrient interactions in the elderly diabetic.
Drug Nutr Interact
May 1989
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.
Elderly diabetics take more drugs than other groups of elderly patients. Their multiple drug use is largely explained by the drugs that they take for complications of their primary disease; these include cardiovascular drugs for macrovascular disease and antibiotics for secondary infections. They also take more drugs for control of other conditions that are etiologically associated with the development and progression of their diabetes, including antihypertensive agents, antilipemic agents and steroids, and nonsteroidal antiinflammatory drugs (NSAIDs), which are taken for relief of joint pain that is intensified by arthritic joints bearing excess weight.
View Article and Find Full Text PDF[Clinical picture and differential diagnosis of the pseudo-stroke syndrome in urgent somatic pathology].
Zh Nevropatol Psikhiatr Im S S Korsakova
December 1987
A clinical and pathomorphological examination has covered 206 subjects who died due to various urgent somatic abnormalities (myocardial infarction, pulmonary thromboembolism, pneumonia, etc.) whose clinical picture was largely characterized by general cerebral and focal neurological symptoms. To denote the aforementioned conditions, the term "pseudo-stroke" has been utilized.
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