Rats immunized with a semipurified preparation of the Escherichia coli heat-stable (ST) enterotoxin conjugated with a protein carrier were protected against challenge with semipurified or purified ST and viable organisms of multiple heterologous serotypes that produce only ST (LT-/ST+), but they were not protected against heal-labile (LT) toxin or viable strains which produce LT either alone (LT+/ST-) or together with ST (LT+/ST+).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC350915PMC
http://dx.doi.org/10.1128/iai.34.2.637-639.1981DOI Listing

Publication Analysis

Top Keywords

rats immunized
8
escherichia coli
8
coli heat-stable
8
heat-stable enterotoxin
8
protection rats
4
immunized escherichia
4
enterotoxin rats
4
immunized semipurified
4
semipurified preparation
4
preparation escherichia
4

Similar Publications

Mechanistic study of the effect of a high-salt diet on the intestinal barrier.

Sci Rep

January 2025

School of Health Preservation and Rehabilitation, Chengdu University of TCM, Shierqiao Road, Chengdu, 610075, Sichuan, People's Republic of China.

Despite the established link between chronic high salt diet (HSD) and an increase in gut inflammation, the effect of HSD on the integrity of the intestinal barrier remains understudied. The present study aims to investigate the impact of HSD on the intestinal barrier in rats, encompassing its mechanical, mucous, and immune components. Expression levels of intestinal tight junction proteins and mucin-2 (MUC2) in SD rats were analyzed using immunofluorescence.

View Article and Find Full Text PDF

Effects of melatonin on the pharmacokinetics and amino acid metabolism profile of vigabatrin in rats.

Toxicol Appl Pharmacol

January 2025

School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Provincial Laboratory of Inflammatory and Immune Disease, Anhui Institute of Innovative Drugs, Hefei, Anhui 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, PR China. Electronic address:

Objectives: Investigating the effect of melatonin (MLT) on the pharmacokinetics and related neurotransmitter and amino acid metabolism of vigabatrin (VGB) in epileptic rats in vivo.

Methods: High performance liquid chromatography was used to examine the pharmacokinetics and tissue distribution of VGB after intragastric administration dosing (50,100,200) mg/kg singly or in combination with melatonin (20 mg/kg) in rats. The single-compartment model of first-order elimination was fitted with the nonlinear mixed-effect model of first-order estimation.

View Article and Find Full Text PDF

Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6.

Neuroscience

January 2025

Department of Physiology, College of Medicine, Health Sciences Centre, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address:

Maternal immune activation (MIA) induces long-term cognitive impairments by modulating the gamma-aminobutyric acid (GABA)ergic system. Experimental evidence suggests that maternal immune challenge with bacterial active ingredient lipopolysaccharide (LPS) reduces GABAergic tone in the offspring's prefrontal cortex. In this study, we aimed to assess whether interleukin-6 (IL-6) contributes to this reduced GABAergic system in the prefrontal cortex of juvenile offspring.

View Article and Find Full Text PDF

Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated in modulating IRI, and plays a pivotal role in regulating host inflammatory and immune responses, but its specific role in liver transplantation IRI remains unclear. This study explores whether can mitigate IRI and its underlying mechanisms.

View Article and Find Full Text PDF

The Mechanism of Bovis Culus Sativus Protecting BBB Damage in Stroke: Insights from Network Pharmacology, Bioinformatics, and Experiments.

J Ethnopharmacol

January 2025

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, 611137 , P.R. China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P.R. China. Electronic address:

Ethnopharmacological Relevance: Bovis calculus (BC) has a medicinal history of over 2,000 years in treating stroke in China. Bovis Culus Sativus (BCS) has similar pharmacological effects to BC. Due to the scarcity of BC, BCS is often used as a substitute for BC in clinical practice for treating stroke in traditional Chinese medicine.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!