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Enhanced in-vitro activity of liposome-trapped penicillin-G against Pseudomonas aeruginosa.
J Chemother
April 1990
Department of Experimental Physiology, School of Health Sciences, Athens, Greece.
The growth inhibition of four Pseudomonas aeruginosa strains by liposome-trapped penicillin-G was investigated. There were indications of an association of the efficacy of liposomal penicillin-G with the nature of the 0-antigenic polymeric side chain. Namely, P28-800 and PCF-95 strains, characterized by a rough polysaccharide chain, were the most susceptible, whereas strain P28-0, possessing an intact lipopolysaccharide, resisted the activity of the entrapped drug.
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