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The relationship between folic acid deficiency and preeclampsia-like phenotypes in rats.
BMC Pregnancy Childbirth
March 2025
Department of obstetrics, Affiliated Hangzhou First People's Hospital, School Of Medicine, Westlake University, Hangzhou, Zhejiang, China.
Background: Pre-eclampsia is a significant contributor to maternal and neonatal morbidity and mortality. However, its etiology remains elusive. More and more studies have highlighted the potential involvement of folic acid metabolism in the development of pre-eclampsia.
View Article and Find Full Text PDFPrognostic Significance of Homocysteine Levels in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Propensity Score Matching and Weighting Analysis.
Rev Cardiovasc Med
February 2025
Prevention & Healthcare Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, 030032 Taiyuan, Shanxi, China.
Background: Elevated homocysteine (Hcy) levels have been linked to poorer outcomes in acute coronary syndrome. This study aimed to assess the predictive value of elevated Hcy levels for major adverse cardiac events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).
Methods: This retrospective cohort study included 183 STEMI patients who underwent primary PCI at a tertiary university hospital in southern China from January 2020 to December 2021.
Estimated stearoyl-CoA desaturase activity mediates the associations of total cysteine with adiposity: The Maastricht Study.
J Clin Lipidol
November 2024
Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands (Drs Tore, Adriaans, Dagnelie, van Greevenbroek); CARIM, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (Drs Tore, Adriaans, Kooi, Dagnelie, Eussen, van Greevenbroek).
Background: Plasma sulfur amino acids (SAAs), particularly cysteine, are associated with obesity. One proposed mechanism is the altered regulation of the stearoyl-CoA desaturase (SCD) enzyme. Changes in the SCD enzyme activity have been linked to obesity, as well as to plasma SAA concentrations.
View Article and Find Full Text PDFAssociations between serum metabolic syndrome indicators levels and cerebrospinal fluid pathological protein in dementia and pre-dementia patients.
J Alzheimers Dis
February 2025
Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Background: Metabolic syndrome (MetS) was associated with an increased incidence of mild cognitive impairment (MCI) and progression to dementia.
Objective: To study the associations between MetS indicators and cerebrospinal fluid (CSF) biomarkers in the participants.
Methods: 61 normal cognition, 66 mild MCI, and 135 dementia participants were included in our study, with the results of lumbar puncture and peripheral blood biochemistry.
Association of Homocysteine, S-Adenosylhomocysteine and S-Adenosylmethionine with Cardiovascular Events in Chronic Kidney Disease.
Nutrients
February 2025
Department of Internal Medicine IV, Saarland University Medical Center, 66421 Homburg, Germany.
Patients suffering from chronic kidney disease (CKD) have a high risk of premature cardiovascular morbidity and mortality. It has been suggested that elevated homocysteine (Hcy) or disturbances in the transmethylation pathway may contribute to this high cardiovascular risk burden due to epigenetic mechanisms. The objective of this study was to explore the prognostic value of Hcy, S-adenosylhomocysteine (SAH) and S-adenosylmethionine (SAM) (one-carbon (C1)-metabolites) among patients with CKD.
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