[Plasma insulin, C-peptide and glucose concentrations in type I diabetic children after a morning injection of insulin (author's transl)].

Plasma levels of insulin, C-peptide and glucose were monitored for 24 hours after a single injection of a mixture of regular and protamine zinc insulin in 22 diabetic children. Results were compared with those in 7 control children. They indicate that plasma insulin in diabetic children is similar or higher than that in controls over the entire time of survey. Plasma insulin is usually high in the first part of the day. However, important variations were observed from one patient to another and, in the same patient, from one day to another. These results stress the necessity of a daily individual adaptation of the doses in diabetic children and adolescents treated with one or several daily injections of insulin.