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Background: Childhood obesity and the rate of its spread is a serious threat to the reproductive health of the nation, especially among boys, being a background for delaying sexual development and further disrupting fertility.
Aim: To study the peculiarities of the ratio of the level of leptin and a number of toxic and essential chemical trace elements in biological environments in adolescent boys aged 13-14 years with obesity and delayed sexual development.
Materials And Methods: Three groups of adolescents aged 13-14 years were studied and formed: the main ones - with constitutional exogenous obesity of 1-2 degrees (1-20 boys without secondary signs of puberty; 2 - 24 boys with 2-4 stages of puberty according to Tanner) and comparisons (3 - 15 boys with normal body weight and without deviations in puberty).
[Assessment of species diversity of anaerobic intestinal microbiota in children and adolescents with exogenous constitutional obesity].
Vopr Pitan
July 2024
Samara State Medical University, Ministry of Health of the Russian Federation, 443099, Samara, Russian Federation.
The problem of the increasing obesity among children and adolescents is urgent. One of the most interesting and promising directions in this area is to study the correlation of individual microorganisms with the presence and absence of obesity. of the study was to assess the correlation between the isolation frequency of individual microorganisms and the presence of obesity in children and adolescents and to identify possible associations between different groups of microorganisms in obese patients.
View Article and Find Full Text PDFSperm chromatin: Evaluation, epigenetic signatures and relevance for embryo development and assisted reproductive technology outcomes.
Eur J Cell Biol
September 2024
Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona ES-17003, Spain; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona ES-17003, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona ES-08010, Spain. Electronic address:
Sperm chromatin is distinct from somatic cell chromatin, as a result of extensive remodeling during the final stages of spermatogenesis. In this process, the majority of histones is replaced with protamines. The chromatin is consequently highly condensed and inert, which facilitates protection of the DNA.
View Article and Find Full Text PDFOxidative Damage of DNA, Proteins and C-Reactive Protein Parameters in Girls and Boys with Exogenous Constitutional Obesity.
Bull Exp Biol Med
January 2024
Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
The parameters of oxidative damage of DNA, proteins, as well as the parameters of the thiol-disulfide system and C-reactive protein in adolescent girls and boys with exogenous constitutional obesity (ECO) were evaluated. In girls and boys with obesity, the levels of 8-hydroxy-2'-deoxyguanosine (marker of DNA destruction) were higher than in controls. Evaluation of the activity of the thiol-disulfide system revealed increased levels of oxidized glutathione (GSSG) and decreased levels of the reduced glutathione (GSH) and GSSG ratio (GSH/GSSG) in adolescents with ECO regardless of the sex in comparison with the control.
View Article and Find Full Text PDFHow biological codes break causal chains to enable autonomy for organisms.
Biosystems
October 2023
School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast BT95DL, UK. Electronic address:
Autonomy, meaning freedom from exogenous control, requires independence of both constitution and cybernetic regulation. Here, the necessity of biological codes to achieve both is explained, assuming that Aristotelian efficient cause is 'formal cause empowered by physical force'. Constitutive independence requires closure to efficient causation (in the Rosen sense); cybernetic independence requires transformation of cause-effect into signal-response relations at the organism boundary; the combination of both kinds of independence enables adaptation and evolution.
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