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Interactive effect of phenylalanine with duration of diabetes on the risk of small vessel disease in Chinese patients with T2DM.
Front Endocrinol (Lausanne)
January 2025
Department of Geriatrics, Tianjin Medical University General Hospital, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, China.
Aims: Few prior studies have explored the relationship between phenylalanine and diabetic small vessel disease (SVD) in patients with different durations of type 2 diabetes mellitus(T2DM). Our study aimed to explore whether phenylalanine is associated with the risk of SVD and to further explore whether phenylalanine interacted with the duration of T2DM to alter the risk of SVD.
Materials And Methods: A total of 1,032 T2DM patients were enrolled using the Liaoning Medical University First Affiliated Hospital (LMUFAH) system.
Supramolecular Combination Chemotherapy: Directly Inducing Immunogenic Cell Death To Inhibit Tumor Metastasis via Host-Guest Interactions.
ACS Appl Mater Interfaces
January 2025
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, P. R. China.
Tumor metastasis is a difficult clinical problem to solve due to tumor heterogeneity and the emergence of antiapoptotic clones driven by tumor evolution. Clinical combination chemotherapy remains a standard treatment for solid metastasis tumors but with worse treatment efficiency. It is worth exploring a high-efficiency and low-side-effect therapeutic method to solve solid metastases.
View Article and Find Full Text PDFActivation of sphingosine-1-phosphate receptor 2 (S1PR2) upregulates dihydropyrimidine dehydrogenase (DPD) expression in colon cancer cells.
J Adv Res
January 2025
Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China; Joint Laboratory for Research & Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University, Beijing, China. Electronic address:
Introduction: Dihydropyrimidine dehydrogenase (DPD) is a major determinant of cancer 5-fluorouracyl (5-FU) resistance via its direct degradation. However, the mechanisms of tumoral DPD upregulation have not been fully understood.
Objectives: This study aimed to explore the role of S1PR2 in the regulation of tumoral DPD expression, identifying S1PR2 as the potential target for reversing 5-FU resistance.
Effects of relative microplastic-biochar sizes and biofilm formation on fragmental microplastic retention in biochar filters.
Environ Res
January 2025
Department of Environmental and Sustainable Engineering, Faculty of Engineering, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand; Professor Aroon Sorathesn Center of Excellence in Environmental Engineering, Department of Environmental and Sustainable Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.
Microplastics (MPs) pose significant risks to aquatic life and human health. Conventional water treatment is ineffective in removing MPs, demanding alternative technologies. Biochar exhibits a potential for removing MPs through adsorption and filtration.
View Article and Find Full Text PDFComparison of different disinfection protocols against contamination of ceramic surfaces with biofilm.
Arh Hig Rada Toksikol
December 2024
University of Rijeka Faculty of Medicine, Department of Microbiology and Parasitology, Rijeka, Croatia.
Environmental contamination with biofilm can be a source of healthcare-associated infections. Disinfection with various biocidal active substances is usually the method of choice to remove contamination with biofilm. In this study we tested 13 different disinfection protocols using gaseous ozone, citric acid, and three working concentrations of benzalkonium chloride-based professional disinfecting products on 24-hour-old biofilms formed by two strains on ceramic tiles.
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