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Approved drugs successfully repurposed against based on machine learning predictions.
Front Cell Infect Microbiol
October 2024
Laboratory of Molecular Epidemiology and Experimental Pathology - LR16IPT04, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- Drug repurposing is a cost-effective method to find new treatments for Neglected Tropical Diseases like Leishmaniasis, utilizing existing FDA-approved drugs.
- In a recent study, five out of ten predicted drug candidates showed effective anti-leishmanial properties, with Acebutolol, Prilocaine, and Phenylephrine being newly identified as potential treatments.
- Two compounds, Dibucaine and Domperidone, demonstrated particularly low inhibitory concentrations (IC values), indicating strong antileishmanial activity without significant toxicity to host cells.
Anti-plasticizing effect of water on prilocaine and lidocaine - the role of the hydrogen bonding pattern.
Phys Chem Chem Phys
May 2024
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
It is generally accepted that water, as an effective plasticizer, decreases the glass transition temperatures (s) of amorphous drugs, potentially resulting in physical instabilities. However, recent studies suggest that water can also increase the s of the amorphous forms of the drugs prilocaine (PRL) and lidocaine (LID), thus acting as an anti-plasticizer. To further understand the nature of the anti-plasticizing effect of water, interactions with different solvents and the resulting structural features of PRL and LID were investigated by Fourier transform infrared spectroscopy (FTIR) and quantum chemical simulations.
View Article and Find Full Text PDFTheoretical Studies of DNA Microarray Present Potential Molecular and Cellular Interconnectivity of Signaling Pathways in Immune System Dysregulation.
Genes (Basel)
March 2024
School of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Manila 1002, Philippines.
Autoimmunity is defined as the inability to regulate immunological activities in the body, especially in response to external triggers, leading to the attack of the tissues and organs of the host. Outcomes include the onset of autoimmune diseases whose effects are primarily due to dysregulated immune responses. In past years, there have been cases that show an increased susceptibility to other autoimmune disorders in patients who are already experiencing the same type of disease.
View Article and Find Full Text PDFAssessing the Impact of Mandibular Molar Root Length on Success in Supplemental Intraligamentary Injection for Irreversible Pulpitis.
Iran Endod J
January 2024
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Introduction: This study investigates the influence of root length in mandibular molars with irreversible pulpitis on the success of supplemental intraligamentary injection following an inferior alveolar nerve (IAN) block. Various factors, including anatomical location, tooth type, and anesthetic solution, may affect supplemental anesthesia success.
Materials And Methods: A total of 251 patients diagnosed with irreversible pulpitis in mandibular first or second molars underwent buccal infiltration anesthesia (4% articaine with 1:100,000 epinephrine) after IAN block injection (3% prilocaine and 0.
Effect of local anesthetics on renal function: An animal study in Iran.
Dent Res J (Isfahan)
October 2023
Postgraduate Student, Dental Students' Research Committee, Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Although most of the metabolism of local anesthetics (LAs) takes place in the liver, no study has investigated the effect of these anesthetics on the kidney function of single-kidney humans or animals. The present study was conducted to examine the effect of LAs on renal function in single-kidney rats.
Materials And Methods: The present experimental animal study with two control groups was done in an animal laboratory.
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