Three separate topics are covered in this review. The first deals with the technique of signal averaging. The concept of ensemble averaging is explored, and alternatives to this traditional tool are considered such as crosscorrelation averaging, latency corrected averaging, median averaging, etc. Different measures of variability of single evoked potentials are finally discussed. The second topic deals with modeling of the evoked potentials. The direct and inverse problems of source localization are discussed. Recent results of the application of these techniques to single evoked potentials are given. The third topic deals with the use of principal components for signal representation and comparison. Geometric consideration and varimax rotation of coefficients are discussed and examples given.
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Int J Gen Med
January 2025
Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, 100049, People's Republic of China.
Objective: Acute unilateral vestibulopathy (AUVP) is quite common in clinical practice, but lesion localization and etiological diagnosis of AUVP remain the current clinical challenges, and have always been the focus for researchers. The study aimed to explore the lesion site and possible etiology of AUVP.
Methods: This study is a retrospective study.
J Pain Res
January 2025
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Purpose: Spinal cord stimulation (SCS) is pivotal in treating chronic intractable pain. To elucidate the mechanism of action among conventional and current novel types of SCSs, a stable and reliable electrophysiology model in the consensus animals to mimic human SCS treatment is essential. We have recently developed a new in vivo implantable pulsed-ultrahigh-frequency (pUHF) SCS platform for conducting behavioral and electrophysiological studies in rats.
View Article and Find Full Text PDFJ Headache Pain
January 2025
Department of Neurology, University of Utah, 383 Colorow Drive, Salt Lake City, UT, 84108, USA.
A key unanswered question in migraine neurobiology concerns the mechanisms that make the brain of migraineurs susceptible to cortical spreading depression (CSD, a spreading depolarization that underlies migraine aura and may trigger the migraine pain mechanisms). Important insights into this question can be obtained by studying the mechanisms of facilitation of CSD initiation in genetic mouse models of the disease. These models, all generated from families with hereditary migraine, allow the investigation of the functional consequences of disease-causing mutations at the molecular, cellular, synaptic and neural circuit levels.
View Article and Find Full Text PDFActa Neurochir (Wien)
January 2025
Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Purpose: To investigate the technique for dorsal median sulcus (DMS) mapping and assess its application value in preserving dorsal columnn (DC) function during intramedullary space occupying surgery based on a single-center experience.
Methods: A retrospective analysis was conducted on 41 cases of intramedullary spinal cord tumor admitted to the Department of Neurosurgery at the First Affiliated Hospital of Xiamen University from March 2017 to August 2023. All included cases underwent intraoperative electrophysiological monitoring, and were divided into a study group (n = 18) and a control group (n = 23), based on whether DMS mapping technique was utilized.
J Neural Eng
January 2025
Precision Neuroscience, 54 W 21st Street, New York, New York, 10010, UNITED STATES.
Localization of function within the brain and central nervous system is an essential aspect of clinical neuroscience. Classical descriptions of functional neuroanatomy provide a foundation for understanding the functional significance of identifiable anatomic structures. However, individuals exhibit substantial variation, particularly in the presence of disorders that alter tissue structure or impact function.
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