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Initial therapy in patients with pulmonary arterial hypertension and cardiovascular comorbidities.
Eur Respir J
January 2025
INSERM UMR_S 999 « Pulmonary Hypertension: Pathophysiology and Novel Therapies », Hôpital Marie Lannelongue, Le Plessis-Robinson, France
Background: European guidelines recommend initial monotherapy in PAH patients with cardiovascular (CV) comorbidities based on the limited of evidence for combination therapy in this growing population.
Methods: A retrospective analysis was conducted on incident PAH patients enrolled in the French Pulmonary Hypertension Registry between 2009 and 2020. Propensity score matching was used to investigate initial dual oral combination therapy oral monotherapy in patients with at least one CV comorbidity (, hypertension, obesity, diabetes and coronary artery disease).
Social health gradient and risk factors among patients hospitalized for COVID-19 and pre-pandemic respiratory infections. A linked national individual case-control study in Belgium.
Front Public Health
November 2024
Chair in Health and Precarity, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Article Synopsis
- * Data from over 22,000 COVID-19 patients and nearly 7,600 patients with viral pneumonia were analyzed, revealing that men, older adults, and those with lower socio-economic status faced higher hospitalization risks and longer stays in the hospital during the pandemic.
- * The findings suggest that the socio-health gradient for COVID-19 reflects pre-existing inequalities, worsening in the pandemic's second wave among marginalized populations, thereby underscoring the need for integrating social data with clinical information for better health outcomes.
Prognostic value of neutrophil to lymphocyte ratio and lymphocyte counts before durvalumab consolidation after radio-chemotherapy in locally advanced non-small cell lung cancer.
Radiat Oncol
November 2024
Department of Radiation Oncology, Centre Léon Bérard, 28 rue Laennec, Lyon, 69673, France.
Background: Durvalumab, an anti-PD-L1 immune checkpoint inhibitor, after radio-chemotherapy (RCT) has changed the management of locally advanced non-small cell lung cancer (LA NSCLC). A series of retrospective studies have investigated different cut-off of lymphocyte count (LyC) and neutrophil-to-lymphocyte ratio (NLR) to predict survival in LA NSCLC. None of these studies has validated their threshold in an independent group of patients.
View Article and Find Full Text PDFImpaired mucosal IgA response in patients with severe COVID-19.
Emerg Microbes Infect
December 2024
Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC 1408 Vaccinology, CIRI - Centre International de Recherche en Infectiologie, Saint-Etienne, France.
Several studies have investigated the antibody response to SARS-CoV-2, focusing particularly on the systemic humoral immune response and the production of immunoglobulin G (IgG) antibodies. IgA antibodies play a crucial role in protecting against respiratory viral infections but have also been associated with the pathophysiology of COVID-19. We performed a prospective study of 169 COVID-19 patients - 50 with critical/severe (ICU), 47 with moderate (Non-ICU), and 72 with asymptomatic COVID-19 - to explore the humoral immune response to SARS-CoV-2 infection.
View Article and Find Full Text PDFIntimacy and sexual life of females with cystic fibrosis.
J Cyst Fibros
August 2024
Respiratory Medicine and Cystic Fibrosis National Reference Centre, Cochin Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; Université Paris-Cité, Institut Cochin, Inserm U1016, Paris, France; ERN-Lung CF network, Frankfurt, Germany.
Article Synopsis
- The study aimed to explore and describe the sexual issues faced by females with cystic fibrosis (CF), an area that has been largely overlooked in previous research.
- The research involved adult females with CF who were currently or previously in sexual relationships, collecting data through a questionnaire and one-on-one interviews to gain deeper insights into their experiences.
- Results indicated that a significant majority (93.4%) experienced discomfort during intercourse, with common issues including lack of lubrication and pain, highlighting the need for increased awareness and better management of sexual health concerns among females with CF.
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