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PM Exposure Induces Glomerular Hyperfiltration in Mice in a Gender-Dependent Manner.
Toxics
December 2024
Shanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
As one of the most common air pollutants, fine particulate matter (PM) increases the risk of diseases in various systems, including the urinary system. In the present study, we exposed male and female C57BL/6J mice to PM for 8 weeks. Examination of renal function indices, including creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA), and urinary microalbumin, indicated that the kidneys of female mice, not male mice, underwent early renal injury, exhibiting glomerular hyperfiltration.
View Article and Find Full Text PDFA single-domain antibody targeting factor XII inhibits both thrombosis and inflammation.
Nat Commun
September 2024
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- Factor XII (FXII) is crucial for activating the body's intrinsic coagulation pathway and has a previously unclear role in inflammation.
- Treating male mice with a novel antibody (Nb-Fc) that targets FXII significantly reduced arterial thrombosis without disrupting normal blood clotting.
- The study shows that inhibiting FXII can lower inflammation-related symptoms and complications during procedures like extracorporeal membrane oxygenation (ECMO), indicating its potential as a therapeutic target for thrombo-inflammatory diseases.
Interaction of Angiotensin-(1-7) with kinins in the kidney circulation: Role of B receptors.
Peptides
September 2024
Department of Physiology and Biophysics, ICB, UFMG, Belo Horizonte, MG, Brazil. Electronic address:
Changes in renal hemodynamics impact renal function during physiological and pathological conditions. In this context, renal vascular resistance (RVR) is regulated by components of the Renin-Angiotensin System (RAS) and the Kallikrein-Kinin System (KKS). However, the interaction between these vasoactive peptides on RVR is still poorly understood.
View Article and Find Full Text PDFThe Renin-Angiotensin System Involvement in Cisplatin-Induced Nephrotoxicity: An Overview of Physiological and Pathological Mechanisms-A Systematic Review.
Int J Nephrol
May 2024
Department of Endodontics, Faculty of Dentistry, Ilam University of Medical Sciences, Ilam, Iran.
Article Synopsis
- Cisplatin (CDDP) is an effective chemotherapy drug, but its use is limited by kidney damage (nephrotoxicity), which may be linked to the renin-angiotensin system (RAS).
- A systematic review analyzed the relationship between CDDP and RAS by examining nine studies, revealing that RAS activation contributes to kidney damage through inflammatory responses and tissue damage markers.
- The review highlights important gender differences: while inhibiting the RAS can reduce kidney damage in males, it may worsen nephrotoxicity in females, pointing to the need for tailored treatments.
Recent advances in the discovery and development of drugs targeting the kallikrein-kinin system.
J Transl Med
April 2024
Individualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 48149, Münster, Germany.
Background: The kallikrein-kinin system is a key regulatory cascade involved in blood pressure maintenance, hemostasis, inflammation and renal function. Currently, approved drugs remain limited to the rare disease hereditary angioedema. However, growing interest in this system is indicated by an increasing number of promising drug candidates for further indications.
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