Experiments on 80 noninbred rats and 135 rabbits have demonstrated for the first time the possibility of cardioplegia induction with a 0.25% formaldehyde solution. In experimental heterotopic heart transplantation, cardiac function could be restored by perfusion of donor blood within up to 3 hours after cardioplegia. This was associated with restitution of sinus rhythm and direct electrical excitability, with normalization of the intraventricular pressure (for the model described). Histological, histochemical, electron microscopic and electrophysiological studies have shown that low concentrations of formaldehyde solution inhibit myocardial energy metabolism and reversibly inhibit the enzymatic activity, preventing proteolysis and thus contributing to the preservation of heart viability.
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Hydrodynamic characterization of the FtsZ protein from Escherichia coli demonstrates the presence of two types of trimers.
Anal Biochem
January 2025
Laboratorio de Biología Estructural y Molecular BEM, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425 Ñuñoa, Santiago 7800003, Chile; Laboratorio de Biotecnología Vegetal y Ambiental Aplicada, Universidad Tecnológica Metropolitana, Santiago, Chile.
FtsZ is a bacterial protein that plays a crucial role in cytokinesis by forming the Z-ring. This ring acts as a scaffold to recruit other division proteins and guide the synthesis of septal peptidoglycan, which leads to cell constriction. In its native state, the FtsZ protein from Escherichia coli (EcFtsZ) is a multi-oligomer comprising dimers, trimers, tetramers, and hexamers in a dynamic self-association equilibrium depending on its concentration.
View Article and Find Full Text PDFBackground: Alzheimer's disease neuropathologic change (AD-NC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older adults and have been associated with brain atrophy, cognitive decline, and dementia. Since AD-NC and LATE-NC are often comorbid and due to the fact that LATE-NC can only be detected at autopsy, in this work, we combined deformation-based morphometry (DBM) on ex-vivo brain MRI and detailed neuropathological evaluation in a large number of community-based older adults to investigate the difference in brain atrophy patterns associated with AD-NC and LATE-NC.
Method: Cerebral hemispheres from 912 older adults participating in four longitudinal, clinical-pathologic cohort studies of aging were included in this work: MAP, ROS, MARS, and AA Core of the Rush Alzheimer's Disease Research Center (Rush ADRC) (Figure 1).
Developing Topics.
Alzheimers Dement
December 2024
Nanyang Technological University, Singapore, Singapore.
Background: The mitochondrial translocator protein (TSPO) is a biomarker of inflammation associated with aging and Alzheimer's disease (AD). We have previously shown that TSPO plays a critical role in protective immune responses important in AD. Here we investigated the interaction between TSPO immunomodulatory function and aging in the hippocampus, a region severely affected in AD.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Alzheimer's disease neuropathologic change (AD-NC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older adults and have been associated with brain atrophy, cognitive decline, and dementia. Since AD-NC and LATE-NC are often comorbid and due to the fact that LATE-NC can only be detected at autopsy, in this work, we combined deformation-based morphometry (DBM) on ex-vivo brain MRI and detailed neuropathological evaluation in a large number of community-based older adults to investigate the difference in brain atrophy patterns associated with AD-NC and LATE-NC.
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N-chlorination of urea-formaldehyde resin microspheres for antibacterial regenerated cellulose fibers.
Int J Biol Macromol
January 2025
Institute of Functional Textiles and Advanced Materials, College of Textiles & Clothing, Qingdao Key Laboratory of Flame-Retardant Textile Materials, State Key Laboratory of Bio-fibers and Eco-textiles, Qingdao University, Qingdao 266071, China. Electronic address:
Regenerated cellulose fibers are required for widespread antibacterial applications across various fields. N-halamines have been extensively studied and are regarded as a promising candidate for antibacterial purposes. In this work, we focus on investigating the chlorination performance of urea-formaldehyde resin microspheres (UFRs) and using them as antibacterial additives incorporated into the spinning dope to fabricate antibacterial viscose fibers.
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