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New evidence for baroreflex and respiratory chemoreflex-mediated cerebral sympathetic activation in humans.
J Appl Physiol (1985)
February 2025
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Québec, Canada.
The brain is highly innervated by sympathetic nerve fibers; however, their physiological purpose is poorly understood. We hypothesized that unilateral cerebral norepinephrine (NE) spillover, an index of cerebral sympathetic nerve activity (SNA), would be elevated when engaging the baroreflex [via lower-body negative pressure (LBNP; -20 and -40 Torr)] and respiratory chemoreflexes [via carbon dioxide (CO) administration (+8 Torr)], independently and in combination. Twelve young and healthy participants (five females) underwent simultaneous blood sampling from the right radial artery and internal jugular vein.
View Article and Find Full Text PDFSkin absorption of metals derived from hydrogenated stainless particles in human skin: Results from the TITANS project.
Environ Pollut
January 2025
Department of Chemistry and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
Workers involved in the decommissioning and removal of radioactive material from nuclear power plants can come into contact with tritiated dust from stainless steel. This study aimed to investigate metal penetration and permeation after skin contamination with these particles. Static diffusion Franz cells were used with intact, damaged, or broken human skin.
View Article and Find Full Text PDFAnalysis of cellular effects by continuous exposure AT low concentration of tritium.
Radiat Prot Dosimetry
November 2024
Laboratory of Radiological Disasters and Medical Science, International Research Institute of Disaster Science, Tohoku University, 519-1176 Aramaki-aza-Aoba, Aoba-ku, Sendai 980-0845, Japan.
This study investigated the induction of DNA double-strand breaks (DSBs) in the hTERT-immortalized normal human diploid epithelial cells (RPE1-hTERT) continuously exposed to 6000 Bq/ml of tritiated water (HTO) and organically bound tritium (OBT). The relationship of the DSBs induction with the intracellular amount as well as the localization of tritium was also examined. Tritium-labeled thymidine (3H-Thy) and palmitic acid (3H-PA) were used as OBT.
View Article and Find Full Text PDFHomogenous Palladium-Catalyzed Dehalogenative Deuteration and Tritiation of Aryl Halides with D/T Gas.
J Am Chem Soc
November 2024
Process Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Hydrogen isotopically labeled compounds have extensive utility across diverse domains, especially in drug discovery and development. However, synthesis of the labeled compounds with exclusive site selectivity and/or high isotope incorporation is challenging. One widely employed method is heterogeneous palladium(0)-catalyzed (such as Pd/C) dehalogenative deuteration and tritiation with D/T gas.
View Article and Find Full Text PDFSelective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines.
Angew Chem Int Ed Engl
January 2025
Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL, UK.
Pharmaceutical-aligned research endeavors continue to diversify, including via the installation of new chemical functionality and non-classical bioisosteres within drug design. With this, an equally high demand emerges for the direct installation of isotopic substituents into these scaffolds within drug discovery programmes, as isotopologues are essential for the elucidation of the biological efficacy and metabolic fate of the active pharmaceutical ingredient (API). The sulfoximine functional group has recently become established as a high-value unit in this context; however, general and effective methods for the synthesis of deuterium (H, D) and tritium (H, T) labelled analogues have remained elusive.
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