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Unlabelled: Epstein-Barr virus (EBV) is associated with multiple types of cancers, many of which express the key viral oncoprotein Latent Membrane Protein 1 (LMP1). LMP1 is the only EBV-encoded protein whose expression is sufficient to transform both epithelial and B-cells. Although metabolism reprogramming is a cancer hallmark, much remains to be learned about how LMP1 alters lymphocyte oncometabolism.
View Article and Find Full Text PDFSynchronous Diagnosis of Angioimmunoblastic T-Cell Lymphoma and Lung Neuro-endocrine Cancer in a Patient.
J Coll Physicians Surg Pak
November 2024
Department of Haematology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
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View Article and Find Full Text PDFA diagnostic dilemma: distinguishing a sulfasalazine induced DRESS hypersensitivity syndrome from a CD30 + lymphoma in a young patient.
Int J Emerg Med
July 2024
Department of Emergency Medicine, ASZ Aalst, Aalst, Belgium.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity reaction characterized by cutaneous rash, lymphadenopathy, fever, eosinophilia, leukocytosis, and life-threatening organ dysfunctions. We describe the case of a 26 year old patient admitted to the Emergency Department for DRESS syndrome after sulfasalazine treatment for rheumatoid arthritis in the right knee. Whole body computer tomography showed multiple neck, chest, and abdominal lymphadenopathy with splenomegaly, massive ascites and severe hepatic cytolysis.
View Article and Find Full Text PDFInhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment.
J Exp Clin Cancer Res
February 2024
Université Côte d'Azur, INSERM, C3M, 06204, Nice, France.
Article Synopsis
- Angioimmunoblastic T-cell lymphoma (AITL) is a challenging cancer linked to CD4 follicular helper T cells, which have poorly understood metabolic needs, prompting the search for targeted treatments.
- Researchers conducted metabolomic and proteomic analyses on murine models of AITL and confirmed findings with human patient data, revealing that AITL Tfh cells heavily rely on the choline lipid pathway for their survival.
- Targeted treatments using a fatty acid oxidation inhibitor showed increased survival in mice and significant reduction of malignant Tfh cells, suggesting that choline metabolism presents a new therapeutic target for AITL.
From the archives of MD Anderson Cancer Center: Plasmablastic lymphoma presenting as a kidney mass in an immunocompetent patient: Case report and literature review.
Ann Diagn Pathol
December 2023
Department of Pathology, The University of Texas Medical Branch, Galveston, TX, USA. Electronic address:
Article Synopsis
- Plasmablastic lymphoma (PBL) is a rare, aggressive form of lymphoma often seen in immunocompromised individuals, particularly those with HIV or EBV, and usually presents in the oral cavity.
- The reported case involves a 65-year-old man without HIV or EBV who presented with significant abdominal issues and was found to have a large kidney mass diagnosed as PBL, after undergoing various tests and treatments.
- This case is notable because it highlights how PBL can occur in immunocompetent patients and emphasizes the need for more research to improve its diagnosis, especially distinguishing it from similar conditions like plasma cell myeloma.
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