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Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders.
Int J Mol Sci
December 2024
Department of Anatomy, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Neuroimmunology is reshaping the understanding of the central nervous system (CNS), revealing it as an active immune organ rather than an isolated structure. This review delves into the unprecedented discoveries transforming the field, including the emerging roles of microglia, astrocytes, and the blood-brain barrier (BBB) in orchestrating neuroimmune dynamics. Highlighting their dual roles in both repair and disease progression, we uncover how these elements contribute to the intricate pathophysiology of neurodegenerative diseases, cerebrovascular conditions, and CNS tumors.
View Article and Find Full Text PDFMultifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride.
Biomedicines
December 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
: This study explored the potential of MCM-48 mesoporous silica matrices as a drug delivery system for metformin hydrochloride, aimed at improving the therapeutic management of type 2 diabetes mellitus. The objectives included the synthesis and characterization of MCM-48, assessment of its drug loading capacity, analysis of drug release profiles under simulated physiological conditions, and the development of a multifractal dynamics-based theoretical framework to model and interpret the release kinetics. : MCM-48 was synthesized using a sol-gel method and characterized by SEM-EDX, TEM, and nitrogen adsorption techniques.
View Article and Find Full Text PDFThe Impact of Moral Hazard on Healthcare Utilization in Public Hospitals from Romania: Evidence from Patient Behaviors and Insurance Systems.
Healthcare (Basel)
December 2024
Faculty of Industrial Design and Business Management, "Gheorghe Asachi" Technical University of Iași, 700050 Iasi, Romania.
Background/objectives: Moral hazard represents a significant challenge in healthcare systems globally, reflecting the tendency of insured individuals to over-utilize medical services when shielded from the full costs of care.
Methods: This paper investigates the dynamics and implications of moral hazard within the Romanian public hospital sector, offering practical recommendations for healthcare policymakers to mitigate the financial risks associated with excessive healthcare utilization and ensure long-term sustainability. To achieve the objectives of this study, a quantitative research approach utilizing vignettes was employed.
Differential Biological Effects of Extracts-In Vitro Studies on Breast Cancer Models.
Antioxidants (Basel)
November 2024
Cell Biology Laboratory, "Victor Babes" National Institute of Pathology, 050096 Bucharest, Romania.
The increasing popularity of herbal supplements emphasizes the need of scientific data regarding their health benefits and possible toxicological concerns. The complexity of botanical extracts, which include thousands of distinct compounds, contributes to the challenging nature of this endeavor. In this study, we explored the hormetic effects of two extracts on breast cell lines.
View Article and Find Full Text PDFThe Mediating Role of Commercial FOMO Between Adolescents' Need to Belong and Psychological Distress: Advertising Implications on Mental Health.
Psychol Rep
January 2025
Faculty of Psychology and Education Sciences, Alexandru Ioan Cuza University of Iași, Iasi, Romania.
The present study was designed to investigate the impact of advertising on adolescents' mental health. To achieve this, we sought to test the mediating effect of commercial fear of missing out (FOMO) related to gadgets and clothing items on the relationship between the need to belong and psychological distress. The research was conducted on a sample of 335 Romanian adolescents (54.
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