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Microsomal glutathione transferase 1 confers cisplatin resistance of non-small cell lung cancer via interaction with arachidonate lipoxygenase 5 to repress ferroptosis.
Iran J Basic Med Sci
January 2025
Department of Oncology, Cangzhou Central Hospital, Cangzhou061000, Hebei Province, P.R. China.
Objectives: Cisplatin (DDP) resistance remains a primary cause of chemotherapy failure and recurrence of non-small cell lung cancer (NSCLC). Abnormal high microsomal glutathione transferase 1 (MGST1) expression has been found in DDP-resistant NSCLC cells. This study aimed to explore the function and mechanism of MGST1 in DDP resistance of NSCLC cells.
View Article and Find Full Text PDFThoracic Hybrid Lesion: A Rare Case of Two Congenital Malformations.
Cureus
December 2024
Internal Medicine, Hospital Distrital Figueira da Foz, Figueira da Foz, PRT.
Cystic cuboid adenomatous malformations (CCAM) are congenital pulmonary lesions, usually benign, that can progress into malignancy. Bronchopulmonary sequestration (BPS) is another type of malformation that consistsof an ectopic pulmonary tissue mass that doesn't participate in blood-gas exchanges, with vascularization provided by anomalous branches of the thoracic aorta. Hybrid lesions are lesions that have histological features of CCAM but with systemic vascularization, a pathognomonic sign of BPS.
View Article and Find Full Text PDFIncentivizing environmental sustainability for surgical healthcare at a systems level.
BMC Surg
January 2025
Division of Thoracic Surgery, Department of Surgery, Hackensack Meridian School of Medicine, Hackensack Meridian Health Network - Central Region, Edison, NJ, 08820, United States of America.
The healthcare sector contributes up to 4.6% of global greenhouse gas emissions. The surgical system contributes predominantly.
View Article and Find Full Text PDFDoes a Simple Blood Gas Analysis and the Clinical Impression Predict Trauma-Induced Coagulopathy?
Hamostaseologie
January 2025
Department of Anaesthesiology and Intensive Care Medicine, Husum Hospital, Husum, Schleswig-Holstein, Germany.
Objectives: Trauma-induced coagulopathy (TIC) is common in severely injured patients and is associated with significant morbidity and mortality.
Method: The association of two parameters of blood gas analysis (hemoglobin [Hb], base excess [BE]) with standard coagulation tests (SCTs) and rotational thrombelastometry (ROTEM) using the database of the TraumaRegister DGU between 2015 and 2022 was studied. In a stepwise approach, the occurrence of a TIC, the correlations between Hb/BE levels and SCT, as well as ROTEM were calculated respectively.
Gut Microbiome and Metabolite Characteristics Associated With Different Clinical Stages in Non-Small Cell Lung Cancer Patients.
Cancer Manag Res
January 2025
Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Objective: Our research has pinpointed the gut microbiome's role in the progression of various pathological types of non-small cell lung cancer (NSCLC). Nonetheless, the characteristics of the gut microbiome and its metabolites across different clinical stages of NSCLC are yet to be fully understood. The current study seeks to explore the distinctive gut flora and metabolite profiles of NSCLC patients across varying TNM stages.
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