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[Determination of antispermal IgE antibodies in women with infertility and chronic inflammatory pelvic diseases.].
Klin Lab Diagn
June 2020
Russian Medical Academy of Continuing Postgraduate Education, 125445, Moscow, Russia.
Personalized therapy for female infertility means determining of immune mechanisms, including allergic sensitization towards sperm antigens. In order to determine antisperm serum IgE antibodies in women with infertility suffering from pelvic inflammatory diseases, the modified Anti-Spermatozoa Antibody protocol was used (ASA Serum ELISA, Demeditec Diagnostisc, Germany). The modification of the protocol is designed to detect only serum antisperm IgE antibodies carrying Fab fragments to sperm antigens.
View Article and Find Full Text PDFRole of Antisperm Antibodies in Infertility, Pregnancy, and Potential forContraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision.
Vaccines (Basel)
September 2019
Center of Research Excellence on Therapeutic Proteinsand Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Sperm of humans, non-human primates, and other mammalian subjects is considered to be antigenic. The effect of changes in autoimmunity on reproductive cells such as spermatozoa and oocytes play a critical but indistinct role in fertility. Antisperm antibodies (ASAs) are invariably present in both females and males.
View Article and Find Full Text PDF[Immunologically conditioned fertility disorders in men--experience of the immunobiological department of the Institute for Maternal and Child Care].
Ceska Gynekol
December 2004
Ustav pro péci o matku a díte, Praha.
Objective: To provide an overview of the results obtained from the more than ten-year systematic monitoring of the contribution of immunopathological mechanisms to the ethiopathogenesis of fertility disorders in men.
Design: A summarising retrospective study.
Setting: Mother and Child Care Institute, Prague.
Recognition of surface antigens on spermatozoa of the common carp (Cyprinus carpio L., Teleostei) using monoclonal antibodies and scanning electron microscopy.
Eur J Morphol
January 1995
Department of Experimental Animal Morphology and Cell Biology, Agricultural University, Wageningen, The Netherlands.
The distribution of antigenic determinants, recognized by seven anti-carp spermatozoa monoclonal antibodies (MAbs) and two anti-carp spermatogonia MAbs were studied using fresh, unfixed carp spermatozoa. The location of the antigenic determinants was analysed in light- and in scanning electron microscopy, in the latter with the backscattered imaging mode. With all seven anti-carp spermatozoa MAbs a similar regular distribution of the immuno-gold labeling was present on heads, midpieces and tails of carp spermatozoa, whereas with the anti-carp spermatogonia MAbs only low or no labeling was observed.
View Article and Find Full Text PDF[Immunological causes of male infertility].
Allerg Immunol (Paris)
April 1991
Laboratoire d'Immuno-Allergologique, CHRU, Angers.
Sperm (spermatozoa and the various secretions of the accessory glands) with its very complex antigenic system is only produced from puberty and thus at a time when the body has already had a for a long time the facility to respond to an antigenic stimulation with an immune reaction. Because of this, the spermatozoa, in contrast to other cells of the organism, are considered as strangers and may behave as auto-antigens. However, the existence of a haemato-testicular barrier, that prevents all contact between the sperm and the immune system must be recognized in man, its rupture has the consequence of formation of anti-spermatozoa antibodies.
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