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[The cerebrospinal fluid and neurocysticercosis: evolutional aspects of the cellular inflammatory response].

Arq Neuropsiquiatr

December 1987

Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo.

In order to evaluate the cellular component of the inflammatory chronic response, 357 cerebrospinal fluid (CSF) samples from 40 patients with neurocysticercosis (NC) were studied. All patients were treated with usual doses of praziquantel (50 mg/kg/day during 21 days) associated with dexamethasone (12 mg/day). NC diagnosis has been performed considering three basic criteria: the clinical evaluation, the CSF examination, the computed tomography findings.

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Immunologic status of 97 patients with dilating cardiomyopathy (DCMP) and 52 patients with hypertrophic cardiomyopathy (HCMP) was studied; total amount of T-lymphocytes as well as the amount of T-active lymphocytes and B-lymphocytes in the test of E- and EAC-rosette formation, subpopulations of T-lymphocytes (T mu, T g in the EA-rosette formation reaction were determined. HLA-typing in the microlymphocytes toxic test was performed. It was determined that the amount of B- and T-lymphocytes as well as the amount of T mu- and Tg-lymphocytes in patients with HCMP does not practically differ from that in normal subjects.

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The present investigation was designed to detect abnormalities in CMI and the presence of polyclonally activated B cells in patients with HBV positive CAH. We studied the peripheral levels and 3H-thymidine incorporation of three lymphocyte subsets: B lymphocytes, as well as two T cell subsets that are either active or late rosetters with high and low affinity receptors respectively for sheep red blood cells (SRBC). In patients the level of peripheral T active cells was decreased, but they exhibited elevated B cell activation.

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We studied the blood distribution of T and B cells in relation to the etiology and the course of the hepatitis process, in 61 consecutive patients with acute viral hepatitis (AVH). Patients with acute viral hepatitis B showed a significant increase in total T, active T and SmIg cells, lasting the first two weeks of disease. These alterations disappeared in patients with resolving hepatitis.

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