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Lyophilized powder of calf bone marrow hydrolysate liposomes improved renal anemia: In vitro and in vivo evaluation.
PLoS One
December 2024
Department of Research and Development, Jinan Perfect Biological Technology Co., LTD, Jinan, Shandong, China.
This study aimed to find whether oral administration of calf bone marrow hydrolysate liposomes (CBMHL) can improve renal anemia. Calf bone marrow was defatted, papain hydrolyzed, liposomalized and lyophilized. Its hematopoietic ability was proved by the colony formation experiment of umbilical cord blood hematopoietic stem cells in vitro.
View Article and Find Full Text PDFInvestigation of mono-nuclear cobalt(II) complexes with a tri-dentate quinoxalyl-hydrazone ligand for their potential in biological research and interaction with ct-DNA.
Int J Biol Macromol
December 2024
Department of Chemistry, Faculty of Science, Sohag University, Sohag, -82534, Egypt; Department of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia. Electronic address:
The condensing reaction of 2-hydroxy-1-naphthaldehyde with quinoxalyl-2-carbohydrazide resulted in synthesizing of a novel derivative of hydrazone quinoxalyl ligand (Hdpq). The bonding behavior between Hdpq and Co(II) ion was investigated in molar ratios of 1: 1 and 2: 1 to produce two different complexes, Codpq and Co(dpq), respectively. Their chemical structure was verified using several spectroscopic approaches.
View Article and Find Full Text PDFJmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships.
Commun Biol
November 2024
Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, United Kingdom.
2-Oxoglutarate (2OG) dependent N-methyl lysine demethylases (JmjC-KDMs) regulate eukaryotic transcription. We report studies showing that isolated forms of all human KDM4 and KDM5 JmjC enzymes catalyse demethylation of N-methylated Arg-3 of histone H2a. Unexpectedly, the results reveal that KDM4E and, less efficiently, KDM4D catalyse C-4 hydroxylation of Arg-20 of H2a on peptides, recombinant H2a, and calf histone extracts, including when the Arg-20 guanidino group is N-methylated.
View Article and Find Full Text PDF[Huge hematoma caused by gastrocnemius bleeding in left calf following anticoagulant by rivaroxaban in patient after total knee arthroplasty:a case report].
Zhongguo Gu Shang
November 2024
Organization and Personnel Department, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Efficacy of Procaine, With and Without Epinephrine, Compared to Lidocaine in Local Anesthesia for Calves Before Thermocautery Disbudding.
J Vet Pharmacol Ther
November 2024
Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Within the European Union, the use of lidocaine in food-producing animals is restricted due to concerns over human safety. This study compared the clinical effectiveness of procaine, with and without epinephrine, against lidocaine in pain alleviation during thermocautery disbudding in xylazine-sedated calves. The efficacy of local blocks was assessed through needle pricks, and the behavioral reactions to disbudding were scored.
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