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- * They are grouped into categories like antibacterials, antifungals, and antivirals, and are sometimes illegally added to disinfectant products despite regulations banning their use in these items.
- * A new testing method has been developed to analyze 42 different antimicrobials in various disinfection products using advanced techniques, ensuring compliance with safety standards.
Structural and functional comparison of Saccharomonospora azurea strains in terms of primycin producing ability.
World J Microbiol Biotechnol
September 2020
Faculty of Sciences, Institute of Biology, University of Pécs, 7624, Pécs, Hungary.
Emerging and re-emerging microbial pathogens, together with their rapid evolution and adaptation against antibiotics, highlight the importance not only of screening for new antimicrobial agents, but also for deepening knowledge about existing antibiotics. Primycin is a large 36-membered non-polyene macrolide lactone exclusively produced by Saccharomonospora azurea. This study provides information about strain dependent primycin production ability in conjunction with the structural, functional and comparative genomic examinations.
View Article and Find Full Text PDFProteomic insight into the primycin fermentation process of Saccharomonospora azurea.
Acta Biol Hung
December 2016
Department of General and Environmental Microbiology, University of Pécs, Pécs , Hungary.
Saccharomonospora azurea SZMC 14600 is a member of the family Pseudonocardiaceae exclusively used for industrial scale production of primycin a large 36-membered non-polyene macrolide lactone antibiotic belonging to the polyketide class of natural products. Even though maximum antibiotic yield has been achieved by empirically optimized two-step fermentation process, little is known about the molecular components and mechanisms underlying the efficient antibiotic production. In order to identify differentially expressed proteins (DEPs) between the pre- and main-fermentation stages of primycin, comparative 2D-PAGE experiments were performed.
View Article and Find Full Text PDFTreatment of invasive candidiasis in neutropenic patients: systematic review of randomized controlled treatment trials.
Leuk Lymphoma
July 2013
Division of Infectious Diseases, Department of Medicine, University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada.
Candidemia and invasive candidiasis (CIC) is associated with considerable morbidity and mortality, with a paucity of controlled data in neutropenic patients. A systematic review was conducted of available data for the treatment of CIC during neutropenia. A structured OVID search of multiple databases was performed.
View Article and Find Full Text PDFSynthesis of the antifungal macrolide antibiotic (+)-roxaticin.
J Am Chem Soc
September 2003
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
The total synthesis of the antifungal macrolide antibiotic roxaticin has been accomplished. The synthesis relies principally on aldol and directed reduction steps to construct the extended 1,3-polyol array present in the natural product. Three principal nonpolyene containing fragments were assembled and then coupled using Julia olefination and methyl ketone aldol addition reactions.
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