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Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma.
J Immunother Cancer
November 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China
Article Synopsis
- * Researchers screened 200 FDA-approved cardiovascular drugs and identified propafenone, a heart medication, as a potential enhancer of ferroptosis in melanoma treatment.
- * Results showed that combining propafenone with ferroptosis inducers leads to significant tumor regression and improved survival rates in animal models, suggesting its potential to boost immunotherapy responses in melanoma patients.
Background: This study investigated drug-drug interactions in patients with atrial fibrillation taking both a direct oral anticoagulant (DOAC) and an antiarrhythmic drug.
Methods And Results: Using data from the National Health Insurance database (2012-2018), we identified 78 805 patients with atrial fibrillation on DOACs, with 24 142 taking amiodarone, 8631 taking propafenone, 2784 taking dronedarone, 297 taking flecainide, 177 taking sotalol, and 42 772 on DOACs alone. Patients with bradycardia, heart block, heart failure, mitral stenosis, prosthetic valves, or incomplete data were excluded.
Effectiveness of a Triple Antiarrhythmic Drug Strategy for Arrhythmia Recurrence after Persistent Atrial Fibrillation Ablation.
Pacing Clin Electrophysiol
December 2024
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Background And Objective: Treating recurrent atrial arrhythmias after persistent atrial fibrillation (PeAF) ablation is often challenging. This single-center, prospective study aimed to observe the effectiveness of different combinations of oral antiarrhythmic drugs (AADs) in reverting to sinus rhythm (SR) in patients with recurrent atrial arrhythmias after PeAF ablation.
Methods: Forty-five patients who experienced recurrent atrial arrhythmias after PeAF ablation were included.
Evaluation of Amiodarone Administration in Patients with New-Onset Atrial Fibrillation in Septic Shock.
Medicina (Kaunas)
September 2024
Dental-Medicine Department, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, 800008 Galati, Romania.
: New-onset atrial fibrillation (NOAF) is a common cardiac condition often observed in intensive care units. When amiodarone is used to treat this condition, either to maintain sinus rhythm after electrical cardioversion or to control heart rate, complications can arise when a systemic pathology is present. Systemic pathology can result in a decrease in cardiac output and blood pressure, making the management of NOAF and septic shock challenging.
View Article and Find Full Text PDFMULTIPLE KERATINOCYTIC CANCERS AFTER INTAKE OF ANTIHYPERTENSIVES (LISINOPRIL/BISOPROLOL/HCT) AND ANTIARRHYTMICS (PROPAFENONE): THE IMPORTANT NEW LINKS TO THE NITROSO-CONTAMINATION AND THE METABOLIC REPROGRAMMING OF THE FUTURE CANCER CELL.
Georgian Med News
June 2024
3Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria.
Article Synopsis
- The mechanisms behind the development of skin tumors are still not fully understood, particularly regarding the roles of photosensitivity and phototoxicity.
- Recent studies have linked specific nitrosamines, contaminants in common pharmaceuticals, to gene and phototoxicity in humans, raising concerns about their potential carcinogenic effects.
- Long-term use of contaminated medications may contribute to skin cancer risk by interfering with tumor suppressor genes and activating oncogenes, affecting overall cancer development.
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