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Trends and challenges in bispecific antibody production.
J Chromatogr A
January 2025
ProBioGen AG, Berlin, Germany.
Bispecific antibodies (bsAbs) represent a rapidly growing field of therapeutic agents. More bsAbs are being approved worldwide and are in various stages of clinical trials. However, the discovery and production of novel bsAbs presents significant challenges due to their complex structure.
View Article and Find Full Text PDFSpatiotemporal analysis of visceral leishmaniasis in Belo Horizonte, Brazil: a historical perspective (1994-2018).
Trans R Soc Trop Med Hyg
January 2025
Programa de Pós-Graduação em Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270901 Belo Horizonte, Minas Gerais, Brazil.
Background: In the Americas, visceral leishmaniasis (VL) results from the zoonotic transmission of Leishmania infantum. VL has a high occurrence rate in the Metropolitan Region of Belo Horizonte (BH), Minas Gerais, Brazil, and has rapidly spread throughout the municipality since it was first recorded in 1994. This research analysed a historical perspective over 25 y of human VL occurrence in BH.
View Article and Find Full Text PDFThe rapidly expanding industrialization and global increase in economic activities have drawn attention to the concerning accumulation of waste. The textile industry plays a significant role in environmental pollution, especially in and water pollution. Harmful dyes used during the fabrication process are mixed with water bodies through sewage or wastewater ejected from industrial factories.
View Article and Find Full Text PDFVirtual hospitals are rapidly being implemented internationally. Research has predominantly focused on clinical outcomes not implementation. We aimed to identify pre-implementation determinants to enable health services to tailor virtual hospital models, increasing likelihood of suitability, acceptability, uptake, clinical effectiveness, and sustainability.
View Article and Find Full Text PDFMultiple Myeloma: Improved Outcomes Resulting from a Rapidly Expanding Number of Therapeutic Options.
Target Oncol
January 2025
Berenson Cancer Center, West Hollywood, CA, USA.
Multiple myeloma (MM) is a bone-marrow-based cancer of plasma cells. Over the last 2 decades, marked treatment advances have led to improvements in the overall survival (OS) of patients with this disease. Key developments include the use of chemotherapy, immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies.
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