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Magnetic particle spray mass spectrometry for the determination of beta-blockers in plasma samples.
Mikrochim Acta
September 2024
Laboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Magnetic particle spray mass spectrometry (MPS-MS), an innovative ambient ionization technique proposed by our research group, was employed to determine beta-blockers in human plasma samples. A dispersive solid phase extraction of atenolol, metoprolol, labetalol, propranolol, nadolol, and pindolol was carried out using magnetic molecularly imprinted polymer (M-MIP) particles that were attached to the tip of a metal probe, which was placed in the mass spectrometer inlet. A solvent (1% formic acid in methanol) was dispensed on the particles, and the Taylor cone was formed around them (in high voltage).
View Article and Find Full Text PDFDetermination of oxprenolol, methandienone and testosterone in meat samples by UHPLC-Q-ToF.
Heliyon
February 2023
Department of Analytical Chemistry, Kuban State University, Krasnodar, 350040, Russia.
The presence of some drugs in meat samples can cause threat to human health, therefore, its analysis is highly desirable for food safety purposes. In this work, a solid-phase extraction procedure for the determination of oxprenolol, a non-selective beta-blocker, and such anabolic agents as methandienone and testosterone in beef meat samples has been developed. Extraction conditions were optimized to achieve high sensitivity and accuracy of the results.
View Article and Find Full Text PDFAqueous liquid chromatography with mobile phases of sodium dodecyl sulphate and ionic liquid.
J Chromatogr A
January 2023
Departament de Química Analítica, Universitat de València, c/Dr. Moliner 50, Burjassot, Spain. Electronic address:
In conventional reversed-phase liquid chromatography (RPLC) with hydro-organic solvents, basic cationic solutes yield retained, broad, asymmetric peaks, owing to their interaction with free anionic silanols in the stationary phase. RPLC mobile phases to which the anionic surfactant sodium dodecyl sulphate (SDS), or an ionic liquid (IL) are added, have been proposed as solutions, since these additives are able to block the silanol effect thus improving the chromatographic performance. With these additives, it is however necessary to increase the elution strength by adding an organic solvent, such as an alcohol or acetonitrile.
View Article and Find Full Text PDFBeta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Neurol Res
April 2023
Department of Physical Therapy, College of Health Care, China Medical University, Taichung, Taiwan.
Background: This present study was undertaken to determine whether beta-blockers produce the cutaneous analgesic effect, comparing them with the long-acting local anesthetic bupivacaine.
Methods: Using a rat model of infiltrative cutaneous analgesia, the effect of 5 beta-blockers (oxprenolol, carteolol, butaxamine, metoprolol, and acebutolol) and bupivacaine was compared and eventually combined with epinephrine.
Results: Among 5 beta-blockers, oxprenolol exhibited the most potent and the longest duration of cutaneous analgesia.
The atypical β-blocker S-oxprenolol reduces cachexia and improves survival in a rat cancer cachexia model.
J Cachexia Sarcopenia Muscle
February 2023
Departament de Bioquímica i Biomedicina Molecular, Cancer Research Group, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Article Synopsis
- The study tests the effectiveness of two stereoisomers of oxprenolol (S-oxprenolol and R-oxprenolol) in combating cancer cachexia using rat and mouse models, with S-oxprenolol showing superior results.
- S-oxprenolol significantly reduced mortality and body weight loss compared to R-oxprenolol, demonstrating a clear dose-dependent effect on overall health and muscle mass in the Yoshida rat model.
- While S-oxprenolol improved certain quality of life indicators, such as food intake and grip strength, both stereoisomers had no notable impact on heart function or structure in the doses tested.
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