Soluble receptors for FcIgG released from unstimulated human peripheral blood lymphocytes were isolated by affinity chromatography on Sepharose 4B-IgG. This material was shown to interfere with the differentiation of peripheral blood B cells into Ig-secreting cells in cultures stimulated with pokeweek or Nocardia opaca extracts. Neither cell viability nor [3H]thymidine incorporation were altered, but the number of Ig-containing cells and that of Ig-secreting cells were decreased. These effects were dose-related. They were found to be associated with Fc IgG-binding soluble material, since absorption on Sepharose 4B-IgG but not on pepsin-digested F(ab')2 fragments removed the inhibitory activity. This suppressor factor, released by unstimulated lymphocytes, may represent a human analogue of murine immunoglobulin-binding factor (IBF) produced by alloactivated T cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/eji.1830101116 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of cancer cell-released extracellular vesicles: have we become closer to cancer pain treatment?
Extracell Vesicles Circ Nucl Acids
December 2024
Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
The effective management of cancer pain continues to be a challenge because of our limited understanding of cancer pain mechanisms and, in particular, how cancer cells interact with neurons to produce pain. In a study published in , Inyang used a mouse model of human papillomavirus (HPV1)-induced oropharyngeal squamous cell carcinoma to show a role for cancer cell-derived extracellular vesicles (cancer sEVs) in cancer pain. They found that inhibiting the release of sEVs reduced spontaneous and evoked pain behaviors, and that pain produced by sEVs is due to activation of TRPV1 channels.
View Article and Find Full Text PDFThermal Water Reduces the Inflammatory Process Induced by the SARS-CoV-2 Spike Protein in Human Airway Epithelial Cells In Vitro.
Biomedicines
December 2024
Rehabilitation Unit, Department of Neuroscience-DNS, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
: Although treatments using thermal water have yielded beneficial effects in respiratory tract infections, the effects of thermal water under experimental conditions similar to those triggered by SARS-CoV-2 have yet to be evaluated. This study aimed to assess whether thermal water could interfere with the interaction between SARS-CoV-2 and host cells and influence inflammatory factors. : Human nasal epithelial primary cells (HNEpCs) were stimulated with SARS-CoV-2 spike protein in the presence or absence of thermal water or tap water.
View Article and Find Full Text PDFPredictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients.
Emerg Microbes Infect
December 2025
Department of Virology and Biotechnology, National Institute for Research in Tuberculosis, Indian Council of Medical Research (ICMR), Chennai, India.
The identification of individuals with the greatest risk of progression to active tuberculosis (TB) disease from the huge reservoir of () infected individuals continues to remain an arduous ascent in the global effort to control TB. In a two-year prospective study, we analysed metabolic profiles in the unstimulated and TB antigen stimulated QuantiFERON supernatants of 14 healthy household contacts (HHCs) who progressed to TB disease (Progressors) and 14 HHCs who remained healthy (Non-Progressors). We identified 21 significantly dysregulated metabolites in the TB antigen-stimulated QuantiFERON supernatants of Progressors, of which the combination of Malic acid and N-Arachidonoylglycine had maximum AUC of 0.
View Article and Find Full Text PDFGout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls.
Arthritis Res Ther
November 2024
Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur nr.6, Cluj, Napoca, 400349, Romania.
Article Synopsis
- * Research focused on IL1RN rs9973741, highlighting that this gout risk allele (G) is associated with decreased production of the anti-inflammatory cytokine IL-1Ra after stimulation and increased IL-1β production in immune cells.
- * The findings suggest that the genetic variations in the IL1RN-IL1F10 locus influence how immune cells respond to MSU crystals, contributing to the inflammatory processes involved in gout.
Effect of betahistine on pro-inflammatory cytokine expression in autoimmune inner ear disease and Meniere's disease patients.
Laryngoscope Investig Otolaryngol
December 2024
Objective: Betahistine is a partial H1 receptor agonist and a potent H3 receptor antagonist commonly used for the treatment of MD and peripheral vertigo. The aim of this study was to investigate the impact of betahistine on the salt induced cytokine expression profiles of AIED and MD patients.
Methods: Peripheral blood mononuclear cells (PBMCs) were obtained from 24 patients with autoimmune inner ear disease (AIED) or Meniere's disease (MD) during an acute exacerbation of hearing loss.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!