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Real world evidence for altered communication patterns in individuals with autism spectrum disorder.
NPJ Digit Med
March 2025
Research Centre Jülich, Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Jülich, Germany.
Adults with autism spectrum disorder (ASD) may compensate for their social difficulties by resorting to more sequential forms of communication. Here, we study communication preferences in individuals with ASD and neurotypical controls by monitoring smartphone-based communication for verbal, written, and mixed app categories over a period of four months. We find ASD participants to prefer written over verbal communication, underscoring the importance of considering these preferences to facilitate social integration.
View Article and Find Full Text PDFReal world experience with MET inhibitors in MET exon 14 skipping mutated non-small cell lung cancer: largest Indian perspective.
Discov Oncol
March 2025
Medical Oncology, Tata Memorial Hospital, Mumbai, India.
Background: Patients with Non-small Cell Lung Cancer (NSCLC) presenting with Mesenchymal-epithelial transition exon 14 skipping mutation (MET ex14) have an unfavorable prognosis with traditional therapies. MET inhibitors have altered the therapeutic paradigm of NSCLC. MET ex14 skipping alteration is reported in 3-4% cases (N Engl J Med 383(10):944-957, 2020, Cancer Discov 5(8):842-9, 2015).
View Article and Find Full Text PDFCortactin facilitates malignant transformation of dysplastic cells in gastric cancer development.
Cell Mol Gastroenterol Hepatol
March 2025
Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, 37232; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, 37232; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232. Electronic address:
Background & Aims: Epithelial cancer onset occurs through sequential stages of cell lineage conversion and functional dysregulation. Dysplasia is a precancerous lesion defined as a direct precursor to cancer and is histologically defined as a transition stage between pre-cancer and cancer, but molecular and biological mechanisms controlling its transformation to malignancy are underdetermined. Here, we discover the crucial role of the actin stabilization and exosome secretion-regulatory protein cortactin in dysplastic cell transformation to adenocarcinoma.
View Article and Find Full Text PDFCross-modal congruency modulates evidence accumulation, not decision thresholds.
Front Neurosci
February 2025
Institute for Hearing Technology and Acoustics, RWTH Aachen University, Aachen, Germany.
Audiovisual cross-modal correspondences (CMCs) refer to the brain's inherent ability to subconsciously connect auditory and visual information. These correspondences reveal essential aspects of multisensory perception and influence behavioral performance, enhancing reaction times and accuracy. However, the impact of different types of CMCs-arising from statistical co-occurrences or shaped by semantic associations-on information processing and decision-making remains underexplored.
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