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Stiff-person syndrome.
Pract Neurol
January 2025
Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Article Synopsis
- * Symptoms arise from abnormal neuronal excitability due to disrupted GABA and glycine neurotransmission, and SPS can overlap with other autoimmune conditions such as autoimmune epilepsy and progressive encephalomyelitis.
- * Early diagnosis is crucial to prevent irreversible disabilities; the review provides insights into clinical signs that may indicate SPS, along with a diagnostic algorithm and treatment options including immunotherapy and GABA-ergic medications.
Diplopia management in a patient with stiff person syndrome.
Clin Exp Optom
May 2024
Illinois Eye Institute, Illinois College of Optometry, Chicago, IL, USA.
Autologous haematopoietic stem cell transplantation for immune-mediated neurological diseases: what, how, who and why?
Pract Neurol
April 2023
Department of Clinical Neurology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
In carefully selected patients, autologous haematopoietic stem cell transplantation (HSCT) is a safe, highly effective and cost-saving treatment modality for treatment-resistant, and potentially treatment-naïve, immune-mediated neurological disorders. Although the evidence base has been growing in the last decade, limited understanding has led to confusion, mistrust and increasing use of health tourism. In this article, we discuss what autologous HSCT is, which immune-mediated conditions can be treated with it, how to select patients, what are the expected outcomes and potential adverse effects, and how cost-effective this treatment is.
View Article and Find Full Text PDFPediatric stiff limb syndrome with polyautoimmunity of anti-GAD-65, anti-islet cell, and thyroid peroxidase antibodies: A case report and review of literature.
J Neuroimmunol
June 2022
Departments of Pediatrics, Neurology and Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI, United States of America; Division of Pediatric Neurology and the Children's Neurodevelopment Center (CNDC), Hasbro Children's Hospital, Providence, RI, United States of America.
We report an early childhood onset Stiff Limb Syndrome (SLS) in association with unusual polyautoimmunity of GAD-65, anti-islet cell, and Thyroid Peroxidase (TPO) autoantibodies, who has achieved a nearly complete neurological recovery following combined immunotherapy, symptomatic and physical therapy. The patient had normal MRIs of the brain and spinal cord and a negative paraneoplastic work-up. Subsequently, she developed hypothyroidism requiring levothyroxine supplementation.
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