Lethal and mutagenic action of the antibacterial drug dioxidine was studied in bacteria. The mutagenic action of dioxidine is related to rec A-dependent repair process. The effect of the drug was increased due to mutation of rfa in S. typhimurium causing a destruction of the cell wall polyliposaccharide complex. The mutagenic action of dioxidine was studied as applied to isogenic strains of S. typhimurium bearing the pKM-101 plasmid and to strains lacking the plasmid.
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