The changes induced in strains of Pseudomonas pseudomallei and Salmonella typhimurium under the action of D.L-ureidosuccinic acid dihydrazide were characterized. A decrease of the speed of multiplication in vitro and of the oxygen consumption was established. The virulence of the strains was reduced and their susceptibility to phagocytosis in vitro was increased.
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| http://dx.doi.org/10.1016/s0172-5599(80)80021-6 | DOI Listing |
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Five newly synthesized hydrazides: L-aspartic acid dihydrazide, DL-ureido-succinic acid dihydrazide, DL-dihydroorotic acid hydrazide, orotic acid hydrazide, and 2,2'-anhydro-1-(beta-D-arabinofuranosyl)-orotic acid hydrazide were tested for mutagenicity in the Ames test. All these hydrazides except DL-ureidosuccinic acid dihydrazide were found to be non-mutagenic. The mutagenic activities of the latter compound which causes base-pair substitution was decreased in the presence of metabolic activator.
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