A double-blind, randomized trial was carried out in 52 patients with infected dermatoses to compare the efficacy and tolerance of two topical antibiotic/steroid combinations in cream formulations, one containing triamcinolone acetonide, neomycin sulphate and undecenoic acid ('Silderm') and the other triamcinolone acetonide, neomycin sulphate, nystatin and gramicidin. Patients applied the cream 3-times daily for 7 days. Assessments carried out before and after treatment showed that the 'Silderm' formulation was the more effective of the two preparations in reducing the extent of lesion, cosmetic disfigurement and irritation, and patients reported a greater improvement in their condition than did those on the other cream. No side-effects were reported in either treatment group.
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