Sera from 49 patients with procainamide-induced lupus erythematosus or circulating antinuclear antibodies were found to be negative for antibodies to native DNA by the CL immunofluorescence assay. This finding suggests that the CL assay is helpful in discriminating between procainamide-induced and naturally occurring systemic lupus erythematosus. The results further confirm the relatively high degree of specificity of the CL assay for SLE.
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