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Structural elucidation of the O-antigen polysaccharide from shigatoxin-producing E. coli O179 using genetic information, NMR spectroscopy and the CASPER program.
Carbohydr Res
January 2025
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden. Electronic address:
The serological properties of the O-antigen polysaccharide region of the lipopolysaccharides are used to differentiate E. coli strains into serogroups. In this study, we report the structure elucidation of the O-specific chain of E.
View Article and Find Full Text PDFReinvestigation into the role of lipopolysaccharide Glycosyltransferases in protein glycosylation.
Gut Microbes
December 2025
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Protein glycosylation has been considered as a fundamental phenomenon shared by all domains of life. In , glycosylation of flagellins A and B with pseudaminic acid have been rigorously confirmed and shown to be essential for flagella assembly and bacterial colonization. In addition to flagellins, several other proteins including RecA, AlpA/B, and BabA/B in have also been reported to be glycosylated and to be dependent on the lipopolysaccharide (LPS) biosynthetic pathway.
View Article and Find Full Text PDFAntigenicity evaluation of the synthetic trisaccharides related to Plesiomonas shigelloides serotype O51 O-antigen containing an acetamidino group.
Carbohydr Res
January 2025
School of Biotechnology and Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China; School of Life Sciences and Health Engineering, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China; Innovation Center for Vaccine Engineering, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China. Electronic address:
Bacterial surface polysaccharides are widely decorated with diverse rare functional groups. An understanding of the role of these functional groups in immunological activity of the glycans is required for the development of carbohydrate-based treatment against bacterial infectious diseases. Here, the antigenicity evaluation of synthetic trisaccharide 1 related to Plesiomonas shigelloides serotype O51 lipopolysaccharide (LPS) O-antigen and its acetamido derivative 2 was achieved to elucidate the immunological importance of O-antigen structure.
View Article and Find Full Text PDFGenomic characteristics and virulence of common but overlooked Yersinia intermedia, Y. frederiksenii, and Y. kristensenii in food.
Int J Food Microbiol
January 2025
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address:
Article Synopsis
- Three species of Yersinia (Y. intermedia, Y. frederiksenii, and Y. kristensenii), common foodborne pathogens, were analyzed using genomic data to uncover their potential threat, revealing significant genomic diversity and a noteworthy presence in Europe and Asia.
- Y. intermedia demonstrated a high level of accessory genes, suggesting adaptability and the ability to acquire beneficial traits, while all three species contained various mobile genetic elements including plasmids and insertion sequences.
- Differences in antibiotic resistance genes and virulence gene composition were noted, with Y. kristensenii being the most virulent, containing the most virulence genes, while Y. frederiksenii showed unique pathogenic mechanisms.
Structural and Serological Characterization of Yet Another New O Antigen, O86, in Clinical Strains.
Int J Mol Sci
December 2024
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia.
Bacteria from the genus are facultative human pathogens, primarily attacking the urinary tract and wounds. A total of 85 O serogroups have been identified so far among these bacilli. Bprz 86 was isolated from the fistula of a patient in Łódź, Poland.
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