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Morphine-Induced Elevation of Reactive Oxygen Species Attenuates Chemotherapy Efficacy in Diverse Cancer Cell Types.
Curr Mol Med
January 2025
Department of Anesthesiology, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong Province, China.
Background: Morphine, a mu-opioid receptor (MOR) agonist commonly utilized in clinical settings alongside chemotherapy to manage chronic pain in cancer patients, has exhibited contradictory effects on cancer, displaying specificity toward certain cancer types and doses.
Objective: The aim of this study was to conduct a systematic assessment and comparison of the impacts of morphine on three distinct cancer models in a preclinical setting.
Methods: Viability and apoptosis assays were conducted on a panel of cancer cell lines following treatment with morphine, chemotherapy drugs alone, or their combination.
Proteomic profiling of the large-vessel vasculitis spectrum identifies shared signatures of innate immune activation and stromal remodelling.
Arthritis Rheumatol
January 2025
Department of Immunology and inflammation, Imperial College London, UK.
Background: Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large-vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments.
Methods: Plasma proteomic profiling of 184 proteins was performed in two cohorts.
Mechanisms of bodily harm in emergency department youths with ADHD.
Front Child Adolesc Psychiatry
October 2022
Department of Anesthesiology, Yale New Haven Health System, New Haven, CT, United States.
Objectives: We sought to perform a review of emergency department data to illuminate whether there is a difference in the prevalence of severe injuries in patients with ADHD compared to patients without ADHD. We hope to illuminate whether providers should consider inquiring whether their pediatric patients have ADHD to improve long term outcomes.
Methods: This study is a retrospective cohort study of patient records contained in the TriNetX database, specifically of pediatric patients in this database who presented to an emergency department.
Effectiveness of Occlusal Splints in the Management of Temporomandibular Disorders: Comparisons of Treatment Approaches and Digital Versus Conventional Fabrication Techniques.
Cureus
January 2025
College of Dentistry, King Saud University, Riyadh, SAU.
This research explores the types and effectiveness of occlusal splints in managing temporomandibular disorders (TMDs). TMDs encompass a range of musculoskeletal and neuromuscular conditions affecting the jaw, causing pain, limited movement, and discomfort. Occlusal splints, also known as bite guards, are commonly used in dentistry to alleviate TMD symptoms by relaxing jaw muscles, preventing joint trauma, and protecting teeth.
View Article and Find Full Text PDFRemimazolam for Sedation and Trachospray for Topicalization During Flexible Nasal Intubation in a Spontaneously Breathing Patient.
Cureus
January 2025
Anesthesiology and Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, NLD.
When a difficult airway is anticipated, awake tracheal intubation can be considered. Usually, low doses of sedatives are administered during this procedure for minimal sedation and anxiolysis, such as midazolam and remifentanil. The newly developed ultra-short-acting benzodiazepine remimazolam has a pharmacokinetic profile that is more suitable for titration during awake tracheal intubation than the long-acting midazolam.
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