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Semiparametric estimator for the covariate-specific receiver operating characteristic curve.
Stat Methods Med Res
January 2025
CITMAga and Department of Statistics and Operations Research, Universidade de Vigo, Vigo, Galicia, Spain.
The study of the predictive ability of a marker is mainly based on the accuracy measures provided by the so-called confusion matrix. Besides, the area under the receiver operating characteristic curve has become a popular index for summarizing the overall accuracy of a marker. However, the nature of the relationship between the marker and the outcome, and the role that potential confounders play in this relationship could be fundamental in order to extrapolate the observed results.
View Article and Find Full Text PDFHistory of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome.
NPJ Antimicrob Resist
February 2024
Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
The streptothricin antibiotics were among the first antibiotics to be discovered from the environment and remain some of the most recovered antimicrobials in natural product screens. Increasing rates of antibiotic resistance and recognition that streptothricin antibiotics may play a role in countering so-called super-bugs has led to the re-evaluation of their clinical potential. Here we will review the current state of knowledge of streptothricins and their resistance in bacteria, with a focus on the potential for new resistance mechanisms and determinants to emerge in the context of potential widespread clinical adoption of this antibiotic class.
View Article and Find Full Text PDFNucleic acid joining enzymes: biological functions and synthetic applications beyond DNA.
Biochem J
January 2025
School of Science, University of Waikato, Hamilton, Waikato, 3216, New Zealand.
DNA-joining by ligase and polymerase enzymes has provided the foundational tools for generating recombinant DNA and enabled the assembly of gene and genome-sized synthetic products. Xenobiotic nucleic acid (XNA) analogues of DNA and RNA with alternatives to the canonical bases, so-called 'unnatural' nucleobase pairs (UBP-XNAs), represent the next frontier of nucleic acid technologies, with applications as novel therapeutics and in engineering semi-synthetic biological organisms. To realise the full potential of UBP-XNAs, researchers require a suite of compatible enzymes for processing nucleic acids on a par with those already available for manipulating canonical DNA.
View Article and Find Full Text PDFInteractions between Per- and Polyfluoroalkyl Substances (PFAS) at the Water-Air Interface.
Environ Sci Technol
January 2025
Department of Civil and Environmental Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Per- and polyfluoroalkyl substances (PFAS)─so-called "forever chemicals"─contaminate the drinking water of about 100 million people in the U.S. alone and are inefficiently removed by standard treatment techniques.
View Article and Find Full Text PDFA time-varying index for agricultural suitability across Europe from 1500-2000.
Sci Data
January 2025
University of Bern, Wyss Academy for Nature, Bern, 3011, Switzerland.
Throughout the last centuries, European climate changed substantially, which affected the potential to plant and grow crops. These changes happened not just over time but also had a spatial dimension. Yet, despite large climatic fluctuations, quantitative historical studies typically rely on static measures for agricultural suitability due to the non-availability of time-varying indices.
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