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A New Smartphone-Based Cognitive Screening Battery for Multiple Sclerosis (icognition): Validation Study.
J Med Internet Res
January 2025
AIMS Lab, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Background: Cognitive deterioration is common in multiple sclerosis (MS) and requires regular follow-up. Currently, cognitive status is measured in clinical practice using paper-and-pencil tests, which are both time-consuming and costly. Remote monitoring of cognitive status could offer a solution because previous studies on telemedicine tools have proved its feasibility and acceptance among people with MS.
View Article and Find Full Text PDFRHOBTB2 Variant p.Arg511Gln Causes Developmental and Epileptic Encephalopathy Type 64 in an Infant: A Case Report and Hotspot Variant Analysis.
Mol Genet Genomic Med
January 2025
Department of Pediatrics, Taihe County People's Hospital, Fuyang, Anhui, China.
Background: Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of brain disorders. Variants in the Rho-related BTB domain-containing 2 gene (RHOBTB2) can lead to DEE64, which is characterized by early-onset epilepsy, varying degrees of motor developmental delay and intellectual disability, microcephaly, and movement disorders. More than half of the variants are located at Arg483 and Arg511 within the BTB domain; however, the underlying mechanism of action of these hotspot variants remains unexplored.
View Article and Find Full Text PDFChange in spinopelvic mobility 3 months after THA using a direct anterior approach.
Orthop Traumatol Surg Res
January 2025
Orthopaedic Department, Croix St Simon Hospital 125 rue d'Avron, 75020 Paris, France.
Introduction: Spinopelvic kinematics, reflected by the change in spinopelvic tilt (ΔSPT) from a standing position to a flexed seated position, has been associated with the risk of prosthetic impingement and hip dislocation. Some studies have suggested changes in spinopelvic mobility after total hip arthroplasty (THA), but none have explored changes in mobility in the first three months following THA using a direct anterior approach.
Hypothesis: Our hypothesis was that changes in spinopelvic mobility occur in the first 3 months postoperatively, leading to increased hip mobility and increased spinopelvic kinematic abnormalities.
Weak trunk extensors in adult spinal deformity patients are related to sagittal malalignment and kinematic limitations.
Gait Posture
January 2025
Laboratory of Biomechanics and Medical Imaging, Faculty of Medicine, Saint-Joseph University of Beirut, Beirut, Lebanon; Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers, Paris, France. Electronic address:
Background: Adult spinal deformity (ASD) is associated with muscles' degeneration that affects postural control and outcomes of an eventual corrective surgery. Evaluation of ASD is usually based on static radiographs and more recently on functional assessment. However, there has been limited exploration of muscle strength weakness in ASD.
View Article and Find Full Text PDFDefinition of cage subsidence in transforaminal lumbar interbody fusion (TLIF) approach and posterior lumbar interbody fusion (PLIF) approach - A systematic review.
J Clin Neurosci
January 2025
Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, NY, USA; Department of Neurosurgery, Buffalo General Medical Center, Kaleida Health, Buffalo, NY, USA. Electronic address:
Background: Although cage subsidence is one of the most common phenomenona associated with interbody fusions and was characterized more than 70 years ago, a standardized method for its measurement, detection, and reporting among different lumbar fusion procedures does not exist. Here, we review previously published literature on cage subsidence to present the most common methods for defining subsidence in the posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) techniques.
Methods: A search was completed in PubMed and Embase with inclusion criteria focused on identifying any study that provided descriptions of the method, imaging modality, and subsidence threshold used to define the presence of cage subsidence in study articles published between January 1, 2001 and December 31, 2022.
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