The article discusses the results of the examination of 40 patients with symptomatic renal hypertension (in 15 of whom arterial hypertension followed a malignant course) and 19 patients with IIB-IIIA stages of hypertensive disease (6 of whom had the malignant form). Marked activation of the renin-angiotensin system along with reduced renal blood flow was found in patients with symptomatic renal hypertension. Despite the reduced renal blood flow, patients with the malignant form of hypertensive disease had diminished activity and secretion of renin as well as a considerably increased prostaglandin F2 alpha content and reduced sodium content in the plasma of renal venous and, particularly in the plasma of aortic blood.
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