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In previous laboratory and environmental studies, the Ty1 short-term test showed positive responses (i.e. induced mobility of the Ty1 retrotransposon) to carcinogenic genotoxins.
View Article and Find Full Text PDFRole of a moderately halophilic bacterial consortium in the biodegradation of polyaromatic hydrocarbons.
Mar Pollut Bull
February 2009
Centre for Environmental Studies, Anna University, Guindy, Chennai - 600 025, India.
Polycyclic aromatic hydrocarbons are ubiquitous pollutants in the environment, and most high molecular weight PAHs cause mutagenic, teratogenic and potentially carcinogenic effects. While several strains have been identified that degrade PAHs, the present study is focused on the degradation of PAHs in a marine environment by a moderately halophilic bacterial consortium. The bacterial consortium was isolated from a mixture of marine water samples collected from seven different sites in Chennai, India.
View Article and Find Full Text PDFThe response of Ty1 test to genotoxins.
Arch Toxicol
October 2008
Faculty of Biology, Sofia University, 8 "Dragan Tsankov" Blvd, 1421 Sofia, Bulgaria.
The Ty1 assay is a short-term test for detection of genotoxins based on induction of the transposition of a gene-engineered Ty1 retrotransposon in Saccharomyces cerevisiae cells. Here, we provide evidence that the Ty1 test responds positively in concentration-dependent manner to the carcinogenic genotoxins benz(a)anthracene, benzo(a)pyrene, chenodeoxycholic and taurodeoxycholic free bile acids and to environmental soil samples polluted with carcinogenic substances. The Ty1 test gives negative results with the noncarcinogenic mutagens benz(b)anthracene, benzo(e)pyrene, lithocholic and taurodeoxycholic conjugated bile acids and to soil samples not polluted with carcinogens.
View Article and Find Full Text PDFAlterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation.
Toxicol Appl Pharmacol
March 1998
University of New Mexico College of Pharmacy, Toxicology Program, Albuquerque 87131-1066, USA.
Previous studies performed in this laboratory have shown that certain benzo(a)pyrene (BaP) metabolites, such as benzo(a)pyrene-7,8-dihydrodiol (BaP-7,8-diol) and benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), were more effective in elevating intracellular Ca2+ in normal human peripheral blood mononuclear cell (HPBMC) T and B cells than was BaP. Additionally, it has been shown that the suppression of human T cell mitogenesis produced by polycyclic aromatic hydrocarbons (PAHs) and certain BaP metabolites is reversed by treatment with alpha-naphthoflavone (ANF), a cytochrome P450 1A and 1B inhibitor. ANF also diminishes the elevation in intracellular calcium (Ca2+) produced by BaP in HPBMC.
View Article and Find Full Text PDF[Mutagenicity and amounts of polycyclic aromatic hydrocarbons in marijuana smoking tar extracted from pipes].
Nihon Eiseigaku Zasshi
February 1992
Department of Public Health, Jikei University School of Medicine, Tokyo.
In spite of strict laws prohibiting it, criminal cases involving marijuana abuse are increasing, resulting in a serious social problem in Japan. The most common method of ingestion is smoking, since abusers feel that this method produces quick psychological effects controversial. Marijuana is known to induce psychological addiction, but it's genotoxic effects are still argued.
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