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Comparison of the effect of Sacubitril/Valsartan with Losartan and Captopril in improving right ventricular function in patients with right heart failure, a randomized clinical controlled trial.
J Prev Med Hyg
September 2024
Department of Cardiology, School of Medicine, Health Management and Economics Research Center, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.
Background: There is evidence supporting the efficacy of Sacubitril /Valsartan for improving left heart failure, but few studies have examined its effects on right ventricular (RV) dysfunction. The current study aimed to investigate the effects of Sacubitril /Valsartan on RV dysfunction in patients with right heart failure.
Methods: The current study was a randomized and parallel clinical trial study.
The Captopril Challenge Test Predicts Cardiac Structure and Dysfunction in Primary Aldosteronism.
J Clin Endocrinol Metab
January 2025
Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Context: The captopril challenge test (CCT) is a commonly used confirmation test that identifies the magnitude of renin- and angiotensin II-independent aldosterone production, and thus the presence and severity of primary aldosteronism (PA).
Objective: This study investigated the association between the post-CCT plasma aldosterone concentration (PAC) and cardiovascular remodeling and diastolic dysfunction.
Methods: A total of 540 PA patients with complete CCT and echocardiographic data were retrospectively analyzed.
Captopril DMSA Contribution in the Identification of the Cause of Severe Hypertension in an Otherwise Healthy 5-Year-Old Girl.
Clin Nucl Med
November 2024
From the Department of Pediatrics, School of Medicine, University of Ioannina, Ioannina, Greece.
Article Synopsis
- A 5-year-old girl with previously normal health was diagnosed with stage 2 hypertension, which is not common in young children and often connected to other disorders.
- Despite normal findings in physical exams and imaging tests like ultrasound and CT scans, blood tests indicated a high renin level and slightly elevated aldosterone, hinting at a potential renovascular issue.
- A specialized renal scan (DMSA) indicated a blockage in a small artery in her kidney, which was successfully fixed through a procedure known as arteriography, emphasizing the usefulness of a captopril DMSA scan in identifying minor kidney artery problems.
Severe hydronephrosis complicated with primary aldosteronism: a case report and review of the literature.
J Med Case Rep
October 2024
Department of Endocrinology and Metabolism, Chongqing University Fuling Hospital, No. 2 Gaosuntang Road, Fuling, China.
Article Synopsis
- Primary aldosteronism is marked by high aldosterone and low renin levels, making diagnosis complex when severe hydronephrosis coexists, which can falsely affect test results.
- A 54-year-old man with a history of hypertension and severe hypokalemia faced misdiagnosis of primary aldosteronism due to consistently negative aldosterone-to-renin ratio tests stemming from coinciding severe hydronephrosis.
- After conducting additional tests, including a saline stress test and adrenal vein sampling, the patient underwent successful laparoscopic removal of an adrenal adenoma, leading to initial renal issues but eventual recovery of renal function and potassium levels.
Successful treatment of resistant hypertension and severe complications in a 63-year-old man with primary aldosteronism without adrenalectomy: A case report.
Heliyon
July 2024
Department of Cardiology, the First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, China.
Primary aldosteronism (PA), often due to aldosteronoma, commonly causes secondary hypertension and typically requires surgery. We present a case of an elderly man with longstanding hypertension, complicated by cerebral hemorrhage and myocardial infarction. Enhanced CT imaging identified a right-sided aldosteronoma and left adrenal gland fullness.
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