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A recurrent loss-of-function variant in DRC1 causes non-syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes.
Andrology
January 2025
Institute for Advanced Biosciences, Team Genetics Epigenetics and Therapies of Infertility, University of Grenoble Alpes, Grenoble, France.
Background: Asthenozoospermia, characterized by reduced sperm motility, is a common cause of male infertility. Multiple morphological abnormalities of the sperm flagella (MMAF) represent a severe and genetically heterogeneous form of asthenozoospermia. Over 50 genes have been associated, but approximately half of MMAF cases remain unexplained.
View Article and Find Full Text PDFMyeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy.
Mol Cancer
January 2025
Laboratory of Oncology, Basic Research Center, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
The advent of immunotherapy represents a significant breakthrough in cancer treatment, with immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 demonstrating remarkable therapeutic efficacy. However, patient responses to immunotherapy vary significantly, with immunosuppression within the tumor microenvironment (TME) being a critical factor influencing this variability. Immunosuppression plays a pivotal role in regulating cancer progression, metastasis, and reducing the success rates of immunotherapy.
View Article and Find Full Text PDFSex and gender in perioperative cardiovascular research: protocol for a scoping review.
Syst Rev
January 2025
Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Background: The inadequate inclusion of sex and gender in medical research has resulted in biased clinical guidance and disparities in knowledge and patient outcomes. Despite efforts by regulatory and funding agencies, opportunities to generate sex-specific knowledge are frequently overlooked. While certain disciplines in cardiovascular medicine have made notable progress, these advances have yet to permeate the literature on perioperative cardiovascular complications in non-cardiac surgery.
View Article and Find Full Text PDFOccurrence and enrichment mechanisms of groundwater hexavalent chromium in typical loess area of China.
Environ Pollut
January 2025
Xi'an Center of Mineral Resources Survey, China Geological Survey, Xi'an, China.
Understanding the geochemical mechanisms governing hexavalent chromium (Cr(VI)) in groundwater is essential for mitigating health risks. However, the processes driving Cr(VI) accumulation and migration in loess regions remain insufficiently understood. This study investigated the occurrence, release, and migration mechanisms of Cr(VI) across different groundwater environmental units (GEUs) in the south-central Loess Plateau, China.
View Article and Find Full Text PDFAssociation of Social Vulnerability Index With Declining Recommended Surgical Treatment in Head and Neck Cancer Patients.
Laryngoscope
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
Objective: To investigate the impact of county-level social vulnerability on patients' decision to refuse recommended surgical treatment.
Methods: Retrospective cohort analysis conducted on HNSCC cases documented in the latest available SEER databases from 2000 to 2020; various demographic, including county of residence, and disease-related variables were collected. CDC's Social Vulnerability Index (SVI) was assigned based on patients' county of residence, and patients were subsequently categorized into four SVI quartiles.
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