AI Article Synopsis
- The study examined colostral lymphocytes using two T-cell markers: ANAE staining and E rosettes, to identify T-cell subsets despite membrane structure changes.
- Many colostral lymphocytes shared phenotypes with mature peripheral blood lymphocytes, suggesting their potential role in protecting newborns from infections and aiding immune transfer.
- A significant portion of colostral T lymphocytes were ANAE-negative, resembling thymocyte characteristics, indicating a unique immune profile.
Article Abstract
Colostral lymphocytes were studied using two established T-cell markers: intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.
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| http://dx.doi.org/10.1159/000241602 | DOI Listing |
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