The influence of homosensitization with syngeneic tissue antigens on immune response to adsorbed DPT vaccine and sheep red blood cells (SRBC) was studied in experiments in CBA mice and noninbred white mice. These experiments revealed that preliminary homosensitization suppressed the production of antibodies to the components of adsorbed DPT vaccine, while after immunization with SRBC the immunosuppressing effect of homosensitization was absent.
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