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[Use of prodigiozan and tactivin for treatment of patients with chronic Klebsiella infections].
Zh Mikrobiol Epidemiol Immunobiol
May 2002
Medical Institute, Clinical Hospital No. 4, Minsk, Belarus.
Two-stage immunocorrection in patients with chronic Klebsiella infections by consecutive administration of prodigiozan and tactivin, has been shown to facilitate the restoration of the balance of immunoregulating cells, to enhance proliferative response to T- and B-mitogens, thus producing favorable clinical dynamics. The possibility of chronic Klebsiella infections therapy, based on the use of immunocorrecting preparations (prodigiozan and tactivin) and antibiotics capable of intracellular penetration (sumamed and cyprofloxacin) is discussed.
View Article and Find Full Text PDFEffects of ascorbic acid on lipid peroxidation and functional state of neutrophils at the early period after transurethral resection of the prostate.
Bull Exp Biol Med
November 2000
Chelyabinsk State Medical Academy, Russia.
Intravenous infusion of ascorbic acid in single doses of 500 and 1000 mg over 3 days after transurethral resection of the prostate elevated the content of lipid peroxidation products in the blood, increased the sensitivity of neutrophils to prodigiozan, and reduced the risk of infectious and inflammatory complications.
View Article and Find Full Text PDFLiver resistance to CCl(4)-induced injury after stimulation of macrophages with various preparations.
Bull Exp Biol Med
June 2000
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Acute toxic hepatitis in male Wistar rats was produced by single injection of 40% CCl(4) (0.2 ml per 100 g body weight in oil). Pretreatment with various immunostimulators (bacterial polysaccharides prodigiozan and salmozan; yeast polysaccharides zymosan, peptidoglycan, and mannan; and hydrolytic enzyme egg lysozyme) produced a hepatoprotective effect correlating which the stimulatory influence on macrophages and increasing in the following order: mannan
[Hemorheological indices in patients with amebic abscesses of the liver and their correction].
Vestn Khir Im I I Grek
November 2000
Hemorheological indices were studied in 89 patients. In 61 patients the authors have revealed somewhat increased viscosity potential of blood and negligible changes in the aggregation activity of erythrocytes which is thought by the authors to be due to the saved compensatory potentialities of the organism. In 28 patients with the complicated course of the disease the rheological parameters of blood became worse because of the suppressed compensatory potentialities of organism.
View Article and Find Full Text PDFEffects of prodigiosan and indometophen on the contents and proliferative activity of CFU and CFU-GM as well as GM-CSF prior to radiation were studied in long-term cultures of murine bone marrow. 24 hours and 5 days after administration of prodigiosan and indometophen, respectively, the long-term cultures were exposed to ionising radiation in a dose 2.0 Gy.
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