Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer.
J Immunother Cancer
January 2024
IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France
Article Synopsis
- Triple-negative breast cancer (TNBC) has a poor prognosis, and cathepsin D (cath-D) is a key target for antibody therapies to enhance natural killer (NK) cell activity against tumors.
- This study explored the effectiveness of engineered anti-cath-D antibodies in triggering NK cell-mediated attacks (ADCC) and their potential in combination therapies for TNBC.
- Results showed that the Fc-engineered antibodies activated NK cells and promoted ADCC against TNBC cells, suggesting their promise as a treatment strategy when used alongside other therapies.
Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8 T Cell Localization in the Murine Liver.
J Immunol
June 2022
Division of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia;
Liver-resident CD8 T cells can play critical roles in the control of pathogens, including and hepatitis B virus. Paradoxically, it has also been proposed that the liver may act as the main place for the elimination of CD8 T cells at the resolution of immune responses. We hypothesized that different adhesion processes may drive residence versus elimination of T cells in the liver.
View Article and Find Full Text PDFSialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo.
Biochem J
May 2022
CSL Ltd, Bio21 Institute, Victoria, Australia.
Human Complement Receptor 1 (HuCR1) is a potent membrane-bound regulator of complement both in vitro and in vivo, acting via interaction with its ligands C3b and C4b. Soluble versions of HuCR1 have been described such as TP10, the recombinant full-length extracellular domain, and more recently CSL040, a truncated version lacking the C-terminal long homologous repeat domain D (LHR-D). However, the role of N-linked glycosylation in determining its pharmacokinetic (PK) and pharmacodynamic (PD) properties is only partly understood.
View Article and Find Full Text PDFEpithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface.
J Reprod Immunol
June 2021
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, 4525 MacDonald Research Laboratories, Los Angeles, CA, 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California-Los Angeles, 4525 MacDonald Research Laboratories, Los Angeles, CA, 90095, USA. Electronic address:
Epithelial membrane protein 2 (EMP2) is a tetraspan membrane protein that has been revealed in cancer and placental models to mediate a number of vascular responses. Recently, Emp2 modulation has been shown to have an immunologic effect on uterine NK cell recruitment in the mouse placenta. Given the importance of immune cell populations on both placental vascularization and maternal immune tolerance of the developing fetus, we wanted to better characterize the immunologic effects of Emp2 at the placental-fetal interface.
View Article and Find Full Text PDFAn obstructive role of NK cells on metastatic growth of clear-cell sarcoma cells in a xenoplant murine model.
Mol Clin Oncol
January 2021
Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu 501-1193, Japan.
Clear cell sarcoma (CCS) affects the deep soft tissues in young adults and is known to have high rates of metastasis, including lymphatic metastasis. In our previous study an xenoplant model of CCS was established, which exhibited local tumor growth, lymphatic metastasis, and distant metastasis in SCID-Beige mice. In the current study, the role of NK cells during metastasis in the same xenoplant murine model was investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!