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Sotatercept: A New Era in Pulmonary Arterial Hypertension.
Cardiol Rev
January 2025
Department of Medicine, New York Medical College, Valhalla, NY.
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by proliferative remodeling and obliterative narrowing of the pulmonary vasculature. While outcomes have improved with existing treatments targeting 3 main pathways, there remains a critical need for novel therapies that address different and novel mechanisms of PAH. Sotatercept, recently Food and Drug Administration (FDA) approved, is a groundbreaking fusion protein that binds to activin and growth differentiation factors, rebalancing antiproliferative and pro-proliferative signals to reverse remodeling in both the pulmonary vasculature and the right ventricle.
View Article and Find Full Text PDFProgressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage.
Sci Rep
December 2024
Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Hydrocephalus commonly occurs after subarachnoid hemorrhage (SAH) and is associated with increased morbidity and disability in patients with SAH. Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fibrosis, and glymphatic system injury are considered the main pathological mechanisms of hydrocephalus after SAH. Although the mechanisms of hydrocephalus after SAH are increasingly being revealed, the clinical prognosis of SAH still has not improved significantly.
View Article and Find Full Text PDFExplant pathology in Biliary Atresia post Kasai procedure: a tale of two livers.
Autops Case Rep
October 2024
Sir Ganga Ram Hospital, Pediatric Gastroenterology and Hepatology, New Delhi, India.
Article Synopsis
- - Biliary atresia (BA) is a severe liver condition in infants that causes inflammation and blockage of bile ducts, leading to cirrhosis within two years if untreated.
- - Early diagnosis is crucial, and the best initial treatment is the Kasai procedure, which should be performed within the first two months of life to maximize the chances of success.
- - The outcomes of the Kasai procedure vary, with potential long-term complications requiring liver transplant; pathologists need to differentiate between various liver damage patterns in successful versus failed surgeries for accurate diagnosis.
Tubulointerstitial nephritis with IgM-positive plasma cells complicated by liver failure.
CEN Case Rep
October 2024
Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 14, Nishi 5, Kita-ku, Sapporo, 060-8648, Japan.
Tubulointerstitial nephritis (TIN) is characterized by inflammation of the renal interstitium with the infiltration of immune cells, mainly consisting of T cells. Recently, patients with TIN with the predominant infiltration of immunoglobulin M (IgM)-positive plasma cells were reported, coined IgMPC-TIN. Here we report the case of a 70-year-old woman diagnosed with Fanconi syndrome and renal tubular acidosis.
View Article and Find Full Text PDFTriggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages.
Int Immunopharmacol
December 2024
Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
Article Synopsis
- TREM-1 is a protein important for the immune system, and scientists are studying how it affects a disease called obliterative bronchiolitis (OB).
- In a mouse study, they found that blocking TREM-1 helps reduce the problems caused by OB, while boosting it makes things worse.
- The research suggests that targeting TREM-1 could be a useful way to treat OB by changing how immune cells work.
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